Show simple item record

Expression of prodynorphin-derived peptides and mRNA in guinea-pig cortex

dc.contributor.authorRamsdell, C. D.en_US
dc.contributor.authorMeador-Woodruff, James H.en_US
dc.date.accessioned2006-04-10T15:38:55Z
dc.date.available2006-04-10T15:38:55Z
dc.date.issued1993-08en_US
dc.identifier.citationRamsdell, C. D., Meador-Woodruff, J. H. (1993/08)."Expression of prodynorphin-derived peptides and mRNA in guinea-pig cortex." Neuropeptides 25(2): 131-138. <http://hdl.handle.net/2027.42/30648>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WNR-4C837KT-M3/2/814433ef84f3f9f44b5fffa12891dc4aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30648
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8105414&dopt=citationen_US
dc.description.abstractThe distributions and extent of processing of four prodynorphin-derived peptides (dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and [alpha]-neoendorphin) were determined in ten regions of the cortex as well as in the striatum of the guinea-pig. There were significant differences between concentrations of these peptides in most cortical regions, with [alpha]-neoendorphin being several times more abundant than the other peptides, and dynorphin A (1-17) being present in the least amount. There were significant between-region differences in concentration for each peptide, although most regions had concentrations similar to those seen in the striatum. Concentrations of each peptide tended to be higher in piriform, entorhinal, motor, and auditory cortex than in other cortical regions. The extent of processing of prodynorphin varied across cortical regions as well, primarily due to the extent of processing to [alpha]-neoendorphin. Prodynorphin mRNA levels were not significantly different between cortical regions or from the amount observed in the striatum. Although specific regional variation exists, it appears that in general prodynorphin is expressed and processed in a similar manner in the cortex as in the striatum.en_US
dc.format.extent824000 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleExpression of prodynorphin-derived peptides and mRNA in guinea-pig cortexen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USAen_US
dc.contributor.affiliationumMental Health Research Institute, Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USAen_US
dc.identifier.pmid8105414en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30648/1/0000290.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0143-4179(93)90093-Pen_US
dc.identifier.sourceNeuropeptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.