View Item 

Show simple item record

Nitric Oxide Synthase Activity in Genetic Hypertension

dc.contributor.authorMalinski, T.en_US
dc.contributor.authorKapturczak, M.en_US
dc.contributor.authorDayharsh, J.en_US
dc.contributor.authorBohr, D.en_US
dc.date.accessioned2006-04-10T15:40:02Z
dc.date.available2006-04-10T15:40:02Z
dc.date.issued1993-07-30en_US
dc.identifier.citationMalinski T., , Kapturczak M., , Dayharsh J., , Bohr D., (1993/07/30)."Nitric Oxide Synthase Activity in Genetic Hypertension." Biochemical and Biophysical Research Communications 194(2): 654-658. <http://hdl.handle.net/2027.42/30674>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-45PTVDK-XT/2/15f56a03c3a9467c862235e6b20ef6c4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30674
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7688219&dopt=citationen_US
dc.description.abstractA porphyrinic sensor was used to monitor nitric oxide released from cultured endothelial and vascular smooth muscle cells obtained from genetically hypertensive rats and from a normotensive reference strain of rats. Endothelial cell nitric oxide synthase (the constitutive enzyme) was stimulated with bradykinin, and vascular smooth muscle cell nitric oxide synthase (the inducible enzyme) was induced with interleukin-1[beta]. Both types of cells from hypertensive rats released less nitric oxide than did cells from normotensive rats. The observed deficient nitric oxide release from endothelial and smooth muscle cells may contribute to the elevated vascular tone and increased cell growth described in hypertension.en_US
dc.format.extent280584 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleNitric Oxide Synthase Activity in Genetic Hypertensionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherDepartment of Chemistry, Oakland University, Rochester, MI 48309, USAen_US
dc.contributor.affiliationotherDepartment of Chemistry, Oakland University, Rochester, MI 48309, USAen_US
dc.identifier.pmid7688219en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30674/1/0000318.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/bbrc.1993.1871en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000318.pdf
Size:
274.0KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.