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Vascular Myocyte-Derived Nitric Oxide Is an Autocrine That Limits Vasoconstriction

dc.contributor.authorCharpie J. R. ,en_US
dc.contributor.authorWebb R. C. ,en_US
dc.date.accessioned2006-04-10T15:40:06Z
dc.date.available2006-04-10T15:40:06Z
dc.date.issued1993-07-30en_US
dc.identifier.citationCharpie J. R., , Webb R. C., (1993/07/30)."Vascular Myocyte-Derived Nitric Oxide Is an Autocrine That Limits Vasoconstriction." Biochemical and Biophysical Research Communications 194(2): 763-768. <http://hdl.handle.net/2027.42/30675>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-45PTVDK-YC/2/108789f84ac2fbd27834b915676539c8en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30675
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8343158&dopt=citationen_US
dc.description.abstractVascular myocytes and endothelial cells possess the enzymatic machinery to generate nitric oxide from L-arginine. This study tests the hypothesis that myocyte-derived nitric oxide has an autocrine function to inhibit contraction. Rat aortic rings were placed in muscle baths for isometric force measurement. Denuded and intact rings contracted to N[omega]nitro-L-arginine; L-arginine reversed these contractions. Compared to intact rings, contractile sensitivity to phenylephrine was increased in denuded rings; N[omega]nitro-L-arginine caused a further enhancement of phenylephrine sensitivity. Acetylcholine contracted denuded rings but not intact rings; these contractions were also potentiated by N[omega]nitro-L-arginine. In intact rings contracted with phenylephrine, acetylcholine caused relaxation that was inhibited by N[omega]nitro-L-arginine. Denuded rings did not relax to acetylcholine. In summary, contractile responses of rat aortae to interventions that alter nitric oxide production are the composite of enzymatic activity in both the endothelial cells and myocytes. Thus, myocyte-derived nitric oxide modulates vascular tone.en_US
dc.format.extent371019 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleVascular Myocyte-Derived Nitric Oxide Is an Autocrine That Limits Vasoconstrictionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.identifier.pmid8343158en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30675/1/0000319.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/bbrc.1993.1887en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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