Pyrroloquinoline Quinone Acts with Flavin Reductase to Reduce Ferryl Myoglobin in Vitro and Protects Isolated Heart from Reoxygenation Injury
dc.contributor.author | Xu F. , | en_US |
dc.contributor.author | Mack C. P. , | en_US |
dc.contributor.author | Quandt K. S. , | en_US |
dc.contributor.author | Shlafer M. , | en_US |
dc.contributor.author | Massey V. , | en_US |
dc.contributor.author | Hultquist D. E. , | en_US |
dc.date.accessioned | 2006-04-10T15:45:08Z | |
dc.date.available | 2006-04-10T15:45:08Z | |
dc.date.issued | 1993-05-28 | en_US |
dc.identifier.citation | Xu F., , Mack C. P., , Quandt K. S., , Shlafer M., , Massey V., , Hultquist D. E., (1993/05/28)."Pyrroloquinoline Quinone Acts with Flavin Reductase to Reduce Ferryl Myoglobin in Vitro and Protects Isolated Heart from Reoxygenation Injury." Biochemical and Biophysical Research Communications 193(1): 434-439. <http://hdl.handle.net/2027.42/30787> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-45PTVYJ-1BB/2/7afc82564f18d3a90a7ac3d01983e76b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30787 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8389151&dopt=citation | en_US |
dc.description.abstract | Pyrroloquinoline quinone has been isolated from bacteria and recently has been detected in mammalian tissues and fluids. We report in vitro studies which show that pyrroloquinoline quinone serves as a high-affinity substrate for an erythrocyte "flavin reductase" and that the pyrroloquinoline quinol generated by this catalysis reacts rapidly with ferryl myoglobin radical. Western blot analysis of rat and rabbit heart homogenates detects a cross-reactive protein which has a molecular weight identical to the erythrocyte reductase from the same species. Low concentrations of pyrroloquinoline quinone protect isolated rabbit heart from reoxygenation injury, serving as an effective tissue-protective agent in this model for cellular oxidative damage. We propose that this tissue protection is due to a pyrroloquinoline quinol-mediated reduction of reactive oxygen species. | en_US |
dc.format.extent | 378946 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Pyrroloquinoline Quinone Acts with Flavin Reductase to Reduce Ferryl Myoglobin in Vitro and Protects Isolated Heart from Reoxygenation Injury | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 8389151 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30787/1/0000440.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/bbrc.1993.1642 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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