Axial selectivity of 1,2-nucleophilic additions to 2-(Alkylidene)cyclohexanones: Is it higher than that of 2-cyclohexenones?

You, Zhengqing; Koreeda, Masato

1993-04-23

Citation: You, Zhengqing, Koreeda, Masato (1993/04/23)."Axial selectivity of 1,2-nucleophilic additions to 2-(Alkylidene)cyclohexanones: Is it higher than that of 2-cyclohexenones?." Tetrahedron Letters 34(17): 2745-2748. <http://hdl.handle.net/2027.42/30835>

Abstract: 2-(Alkylidene)cyclohexanones embedded in steroid systems underwent 1,2-addition of both small and sterically demanding nucleophiles to yield exclusively the axial adducts, supporting the suggestion that 2-(alkylidene)cyclohexanones appear to have intrinsically higher axial selectivity than 2-cyclohexenones.

DOIs: http://dx.doi.org/10.1016/S0040-4039(00)73551-9

URI: http://www.sciencedirect.com/science/article/B6THS-42M7GHD-8C/2/648d0f670acf6a17da63eff34cf2bfb2

Handle: http://hdl.handle.net/2027.42/30835

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