Show simple item record

Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration

dc.contributor.authorBazzett, Terence J.en_US
dc.contributor.authorBecker, Jill B.en_US
dc.contributor.authorKaatz, Kevin W.en_US
dc.contributor.authorAlbin, Roger L.en_US
dc.date.accessioned2006-04-10T15:48:39Z
dc.date.available2006-04-10T15:48:39Z
dc.date.issued1993-04en_US
dc.identifier.citationBazzett, T. J., Becker, J. B., Kaatz, K. W., Albin, R. L. (1993/04)."Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration." Experimental Neurology 120(2): 177-185. <http://hdl.handle.net/2027.42/30865>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WFG-45PMT1F-N/2/1df4fce426fc324928515fb70a3ad5b6en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30865
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8387931&dopt=citationen_US
dc.description.abstractThe excitotoxic hypothesis of Huntington's disease pathogenesis suggests that selective striatal neuronal loss results from excessive activation of striatal excitatory amino acid receptors. Using a microdialysis probe mated to an Alzet 2002 mini-osmotic pump three different concentrations of quinolinic acid or vehicle were administered to the striata of rats over a 3-week period. Animals that received a total of 3.3 [mu]mol of quinolinic acid had significant striatal atrophy that could be attributed to two distinct areas of neuronal loss. First, an area of necrosis surrounding the probe was marked by inflammatory infiltrate and a lack of neurons. In the second region, surrounding the necrotic area, there was a significant reduction in nissl-stained cells, with relative sparing of NADPH-diaphorase-staining neurons. In addition, there was a reduction in cytochrome oxidase staining throughout both of the areas of cell loss. Beyond the area of cell loss, the striatum appeared normal in all respects. The striata of animals that received 880 nmol quinolinic acid appeared identical to those that received vehicle. The striata of animals that received 8.8 [mu]mol quinolinic acid showed severe nonselective atrophy of the striatum and some surrounding structures. We conclude that dialytic delivery of 3.3 [mu]mol quinolinic acid produces an area of neuronal destruction that resembles the selective neuronal loss seen in Huntington's disease. This selective neurodegeneration produced by chronic exposure to quinolinic acid simulates more closely the course of Huntington's disease than previously described methods.en_US
dc.format.extent871405 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleChronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degenerationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, Neuroscience Program, and Reproductive Sciences Program, University of Michigan, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Psychology, Neuroscience Program, and Reproductive Sciences Program, University of Michigan, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Neurology, and Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Neurology, and Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA.en_US
dc.identifier.pmid8387931en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30865/1/0000528.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/exnr.1993.1053en_US
dc.identifier.sourceExperimental Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.