Inhibitory effects of clonidine on serotonergic neuronal activity as measured by cerebrospinal fluid serotonin and its metabolite in anesthetized rats
dc.contributor.author | Matsumoto, Machiko | en_US |
dc.contributor.author | Togashi, Hiroko | en_US |
dc.contributor.author | Yoshioka, Mitsuhiro | en_US |
dc.contributor.author | Hirokami, Mitsugu | en_US |
dc.contributor.author | Tochihara, Masahiro | en_US |
dc.contributor.author | Ikeda, Toshiya | en_US |
dc.contributor.author | Smith, Charles B. | en_US |
dc.contributor.author | Saito, Hideya | en_US |
dc.date.accessioned | 2006-04-10T15:58:44Z | |
dc.date.available | 2006-04-10T15:58:44Z | |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Matsumoto, Machiko, Togashi, Hiroko, Yoshioka, Mitsuhiro, Hirokami, Mitsugu, Tochihara, Masahiro, Ikeda, Toshiya, Smith, Charles B., Saito, Hideya (1993)."Inhibitory effects of clonidine on serotonergic neuronal activity as measured by cerebrospinal fluid serotonin and its metabolite in anesthetized rats." Life Sciences 53(8): 615-620. <http://hdl.handle.net/2027.42/31094> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-478B6WK-2JC/2/e33fc1e0919c79cc8d389d72a2bcd210 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31094 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8102468&dopt=citation | en_US |
dc.description.abstract | Clonidine-induced changes in the serotonergic neuronal activity of the central nervous system were estimated by measuring the concentrations of serotonin (5-HT) and its major metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA), in the cerebrospinal fluid (CSF) of anesthetized rats. Clonidine (30 and 300 [mu]g/kg, i.v.) led to 74% and 60% reductions in the concentration of 5-HT in the CSF 60 min after administration. CSF 5-HIAA concentrations were also decreased to 77% and 66%, respectively. Clonidine-induced (30 [mu]g/kg, i.v.) decreases in CSF 5-HT and 5-HIAA concentrations were attenuated by pretreatment with idazoxan (5 mg/kg, i.p.). Idazoxan by itself did not alter the CSF 5-HT and 5-HIAA concentrations. Decreased CSF 5-HT and 5-HIAA concentrations after i.v. administration of clonidine (30 [mu]g/kg) were abolished by noradrenergic denervation after pretreatment with 6-hydroxydopamine (200 [mu]g/rat, i.c.v.). These results suggest the possibility that clonidine acts to inhibit the serotonergic neuronal activity, which is mediated via the [alpha]2-adrenoceptors. It indicates, moreover, that noradrenergic nervous systems are involved in the clonidine-induced inhibition of serotonergic neuronal activity. Therefore, noradrenergic neurons play a significant role in mediating the actions of clonidine on serotonergic neuronal activity in the rat brain. | en_US |
dc.format.extent | 458009 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Inhibitory effects of clonidine on serotonergic neuronal activity as measured by cerebrospinal fluid serotonin and its metabolite in anesthetized rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626, U.S.A. | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060, Japan | en_US |
dc.identifier.pmid | 8102468 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31094/1/0000771.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(93)90270-D | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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