Detection and characterization of nitric oxide synthase in the mammalian cochlea
dc.contributor.author | Fessenden, James D. | en_US |
dc.contributor.author | Coling, Donald E. | en_US |
dc.contributor.author | Schacht, Jochen | en_US |
dc.date.accessioned | 2006-04-10T17:40:50Z | |
dc.date.available | 2006-04-10T17:40:50Z | |
dc.date.issued | 1994-12-30 | en_US |
dc.identifier.citation | Fessenden, James D., Coling, Donald E., Schacht, Jochen (1994/12/30)."Detection and characterization of nitric oxide synthase in the mammalian cochlea." Brain Research 668(1-2): 9-15. <http://hdl.handle.net/2027.42/31105> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-47XN88X-4/2/0f2806e9bcb4d381a380643991212a12 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31105 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7535658&dopt=citation | en_US |
dc.description.abstract | The messenger molecule nitric oxide (NO) is involved in blood flow regulation, cytotoxicity, and neural signalling, processes that are important in the physiology and pathophysiology of the mammalian cochlea. However, neither the presence of NO nor its synthetic enzyme, NO synthase, has been established in the peripheral auditory system. NO synthase activity, measured as the enzymatic conversion of radioactive arginine to citrulline, was predominantly soluble in the auditory nerve, lateral wall, vetibule and cochlear neuroepithelium. and trifluoperazine inhibited NO synthase activity in the lateral wall and auditory nerve. Histochemical staining by NADPH-diaphorase localized NOS activity to the lateral wall and the neuronal elements of the organ of Corti. Based on these results, the predominant NO synthase isoform in the cochlea is the neuronal type-I isoform. | en_US |
dc.format.extent | 673609 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Detection and characterization of nitric oxide synthase in the mammalian cochlea | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-0506, USA. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-0506, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-0506, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. | en_US |
dc.identifier.pmid | 7535658 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31105/1/0000001.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(94)90505-3 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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