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The Bcl-2 family of proteins: regulators of cell death and survival

dc.contributor.authorNunez, Gabrielen_US
dc.contributor.authorClarke, Michael F.en_US
dc.date.accessioned2006-04-10T17:47:11Z
dc.date.available2006-04-10T17:47:11Z
dc.date.issued1994-11en_US
dc.identifier.citationNunez, Gabriel, Clarke, Michael F. (1994/11)."The Bcl-2 family of proteins: regulators of cell death and survival." Trends in Cell Biology 4(11): 399-403. <http://hdl.handle.net/2027.42/31217>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TCX-47G9R6P-4T/2/07cc343f2be29cc702aaf3458150a3feen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31217
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14731816&dopt=citationen_US
dc.description.abstractThe Bcl-2 protein inhibits apoptosis induced by a variety of signals, in a range of cell types and in diverse organisms, and it is implicated in both normal development and oncogenesis. Despite this central role, the mechanism of action of Bcl-2 is not yet clear. Recent studies have uncovered a number of Bcl-2-related gene products that regulate apoptosis either negatively or positively, and Bcl-2 forms heterodimers with at least one of these proteins, Bax. This article discusses the role of the Bcl-2 family of proteins in the light of these findings.en_US
dc.format.extent897485 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe Bcl-2 family of proteins: regulators of cell death and survivalen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Pathology and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartments of Pathology and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid14731816en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31217/1/0000119.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0962-8924(94)90053-1en_US
dc.identifier.sourceTrends in Cell Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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