GABAB binding sites in early adult and aging rat brain
dc.contributor.author | Turgeon, Sarah M. | en_US |
dc.contributor.author | Albin, Roger L. | en_US |
dc.date.accessioned | 2006-04-10T17:47:52Z | |
dc.date.available | 2006-04-10T17:47:52Z | |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Turgeon, Sarah M., Albin, Roger L. (1994)."GABAB binding sites in early adult and aging rat brain." Neurobiology of Aging 15(6): 705-711. <http://hdl.handle.net/2027.42/31228> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T09-485YBDB-2J/2/ccccfb3085c5f117eb41f35d3d061a45 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31228 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7891825&dopt=citation | en_US |
dc.description.abstract | The effect of aging on GABAB binding was investigated in rat brain. Receptor autoradiography was used to investigate both GABAB and GABAA binding at 2 months, 3 months, 13 months, and 23 months. GABAB binding decreases significantly between 2 months and 23 months of age, as does GABAA binding, with was investigated in rat brain. Receptor autoradiography was used to investigate both GABAB and GABAA binding at 2 months, 3 months, 13 months, and 23 months. GABAB binding decreases significantly between 2 months and 23 months of age, as does GABAA binding, with greatest decrease between 2 and 3 months. The decrease in GABAB binding appears to be due to a decrease in binding site affinity rather than a decrease in receptor density. The noncompetitive GABAB antagonist zinc, the competitive GABAB antagonist CGP 35348, and the guanyl nucleotide analogue GTP-[gamma]-S all inhibit GABAB binding identically in 2 month and 23 month brain. These data indicate subtle age-related changes in the GABAB binding in early adult life but little change with senescence. | en_US |
dc.format.extent | 765122 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | GABAB binding sites in early adult and aging rat brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Program and Department of Neurology, University of Michigan, Ann Arbor MI 48109, USA | en_US |
dc.contributor.affiliationum | Neuroscience Program and Department of Neurology, University of Michigan, Ann Arbor MI 48109, USA | en_US |
dc.identifier.pmid | 7891825 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31228/1/0000130.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0197-4580(94)90052-3 | en_US |
dc.identifier.source | Neurobiology of Aging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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