Tyrosine Kinase Inhibitors Attenuate "Capacitative" Ca2+ Influx in Rat Pancreatic Acinar Cells
dc.contributor.author | Yule D. I. , | en_US |
dc.contributor.author | Kim E. T. , | en_US |
dc.contributor.author | Williams J. A. , | en_US |
dc.date.accessioned | 2006-05-10T15:36:59Z | |
dc.date.available | 2006-05-10T15:36:59Z | |
dc.date.issued | 1994-08-15 | en_US |
dc.identifier.citation | Yule D. I., , Kim E. T., , Williams J. A., (1994/08/15)."Tyrosine Kinase Inhibitors Attenuate "Capacitative" Ca2+ Influx in Rat Pancreatic Acinar Cells." Biochemical and Biophysical Research Communications 202(3): 1697-1704. <http://hdl.handle.net/2027.42/31389> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-45PMMDV-RM/2/8c24736374888998fcb80a75fa669438 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31389 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8060359&dopt=citation | en_US |
dc.description.abstract | The effect of several tyrosine kinase inhibitors was tested on Ca2+ influx mediated by thapsigargin-and CCh-induced intracellular store depletion. Genestein inhibited Ca2+ influx in a concentration dependent manner without affecting Ca2+ release or Ca2+ pumping activity. A measureable effect was observed at 3 [mu]M with total inhibition of influx seen at 100 [mu]M. Tyrphostin A25 (300 [mu]M; 78% inhibition) and methyl 2,5 dihydroxycinnamate (10 [mu]M; 51% inhibition) also inhibited Ca2+ influx. The degree of attenuation was not markedly altered by preincubation of the inhibitors. Genestein also inhibited Ca2+ influx induced by CCh. These data indicate that inhibition of Ca2+ influx could in part underlie the previously reported inhibition of enzyme secretion by these agents. | en_US |
dc.format.extent | 8 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.extent | 428435 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.title | Tyrosine Kinase Inhibitors Attenuate "Capacitative" Ca2+ Influx in Rat Pancreatic Acinar Cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109, USA and Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | University of Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109, USA and Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | University of Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109, USA and Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 8060359 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31389/3/0000303.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/bbrc.1994.2130 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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