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Protective Effects of the SOD-mimetic SC-52608 Against Ischemia/Reperfusion Damage in the Rabbit Isolated Heart

dc.contributor.authorKilgore, Kenneth S.en_US
dc.contributor.authorFriedrichs, Gregory S.en_US
dc.contributor.authorJohnson, C. R.en_US
dc.contributor.authorSchasteen, C. S.en_US
dc.contributor.authorRiley, D. P.en_US
dc.contributor.authorWeiss, R. H.en_US
dc.contributor.authorRyan, U.en_US
dc.contributor.authorLucchesi, Benedict Roberten_US
dc.date.accessioned2006-04-10T17:59:33Z
dc.date.available2006-04-10T17:59:33Z
dc.date.issued1994-08en_US
dc.identifier.citationKilgore, K. S., Friedrichs, G. S., Johnson, C. R., Schasteen, C. S., Riley, D. P., Weiss, R. H., Ryan, U., Lucchesi, B. R. (1994/08)."Protective Effects of the SOD-mimetic SC-52608 Against Ischemia/Reperfusion Damage in the Rabbit Isolated Heart." Journal of Molecular and Cellular Cardiology 26(8): 995-1006. <http://hdl.handle.net/2027.42/31425>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WK6-45P092R-17/2/d470743aadfc98a26bf76862277c6799en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31425
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7799454&dopt=citationen_US
dc.description.abstractAn experimental model of myocardial ischemia/reperfusion injury was used to assess the cardioprotective effects of SC-52608, a low molecular weight superoxide dismutase mimetic. Langendorff perfused rabbit isolated hearts were subjected to 30 min of global ischemia followed by 45 min of reperfusion. Hearts perfused in the presence of 20 [mu]M SC-52608 exhibited a decrease in the release of creatine kinase and intracellular potassium compared to hearts receiving vehicle (control). A progressive increase in left ventricular end-diastolic pressure developed upon reperfusion in all hearts, but was significantly greater in control hearts when compared to hearts with SC-52608 (P &lt; 0.05). In addition, results obtained with a radiolabeled monoclonal antibody to the intracellular protein myosin, indicate an increased degree of irreversible damage in vehicle-treated hearts. Myocardial protection was not significant in an additional group of hearts with 10 [mu]M SC-52608. The hemodynamic, biochemical, morphological, as well as the antimyosin binding data, demonstrate that pretreatment with SC-52608 protects the myocardium from damage associated with global ischemia and reperfusion. The mechanism by which SC-52608 mediates the observed protective effect is most likely related to its ability to scavenge superoxide.en_US
dc.format.extent785879 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleProtective Effects of the SOD-mimetic SC-52608 Against Ischemia/Reperfusion Damage in the Rabbit Isolated Hearten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626en_US
dc.contributor.affiliationumno department foundDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626, and Monsanto Corporate Research, St. Louis, MO 63167, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626, and Monsanto Corporate Research, St. Louis, MO 63167, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626, and Monsanto Corporate Research, St. Louis, MO 63167, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0626en_US
dc.identifier.pmid7799454en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31425/1/0000343.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/jmcc.1994.1120en_US
dc.identifier.sourceJournal of Molecular and Cellular Cardiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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