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Withdrawal from morphine or amphetamine: different effects on dopamine in the ventral-medial striatum studied with microdialysis

dc.contributor.authorCrippens, Donitaen_US
dc.contributor.authorRobinson, Terry E.en_US
dc.date.accessioned2006-04-10T18:00:42Z
dc.date.available2006-04-10T18:00:42Z
dc.date.issued1994-07-04en_US
dc.identifier.citationCrippens, Donita, Robinson, Terry E. (1994/07/04)."Withdrawal from morphine or amphetamine: different effects on dopamine in the ventral-medial striatum studied with microdialysis." Brain Research 650(1): 56-62. <http://hdl.handle.net/2027.42/31444>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-4835Y66-12Y/2/216b6575a91e442d1d08a70d80d68da3en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31444
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7953677&dopt=citationen_US
dc.description.abstractThe effect of withdrawal from chronic morphine or amphetamine treatment on dopamine (DA) neurotransmission in the ventral-medial striatum was studied by use of in vivo microdialysis. There was no effect of 24 h of amphetamine withdrawal on the basal concentration of DA in the ventral-medial striatum. Spontaneous morphine withdrawal (24 h) was associated with a significant decrease in the basal concentration of DA in dialysate, but following morphine replacement and naloxone-precipitated withdrawal variations in withdrawal symptoms were not related to variations in the concentration of DA in dialysate. It is suggested that: (1) the correlation between the extracellular concentration of DA in the ventral-medial striatum and the symptoms of morphine withdrawal may not be indicative of a necessary, causal relationship; and (2) a decrease in the extracellular concentration of DA in the ventral-medial striatum is not a common feature of drug withdrawal syndromes.en_US
dc.format.extent664989 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleWithdrawal from morphine or amphetamine: different effects on dopamine in the ventral-medial striatum studied with microdialysisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron Street, Ann Arbor, MI 48104-1687, USAen_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron Street, Ann Arbor, MI 48104-1687, USAen_US
dc.identifier.pmid7953677en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31444/1/0000364.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(94)90206-2en_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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