Light-Activated Release of Nitric Oxide from Vascular Smooth Muscle of Normotensive and Hypertensive Rats
dc.contributor.author | Kubaszewski, E. | en_US |
dc.contributor.author | Peters, A. | en_US |
dc.contributor.author | Mcclain, S. | en_US |
dc.contributor.author | Bohr, D. | en_US |
dc.contributor.author | Malinski, T. | en_US |
dc.date.accessioned | 2006-04-10T18:12:54Z | |
dc.date.available | 2006-04-10T18:12:54Z | |
dc.date.issued | 1994-04-15 | en_US |
dc.identifier.citation | Kubaszewski E., , Peters A., , Mcclain S., , Bohr D., , Malinski T., (1994/04/15)."Light-Activated Release of Nitric Oxide from Vascular Smooth Muscle of Normotensive and Hypertensive Rats." Biochemical and Biophysical Research Communications 200(1): 213-218. <http://hdl.handle.net/2027.42/31635> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-45PMJBV-H6/2/35462add5fff5aefc76deb408ba0add1 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31635 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8166690&dopt=citation | en_US |
dc.description.abstract | A porphyrinic sensor was used to monitor nitric oxide release from vascular smooth muscle in response to exposure to ultraviolet light. Aortic rings exposed to UV light relaxed with a time course that parallels this observed NO release. With repeated UV light treatments, the magnitude of the relaxations diminished, suggesting that a store of NO was being exhausted. Photorelaxation in response to UV light was studied in aortic rings from two types of hypertensive rats, genetic (SHRSP) and nitroarginine-induced. These aortic rings showed greater photorelaxation and evidenced less tolerance than did aortic rings from control normotensive rats. Since NO synthase activity is depressed in both types of hypertension, it appears, paradoxically, that the UV light-releasable store of NO is augmented when NO synthase activity is depressed. | en_US |
dc.format.extent | 336435 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Light-Activated Release of Nitric Oxide from Vascular Smooth Muscle of Normotensive and Hypertensive Rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationother | Department of Chemistry and Institute of Biotechnology, Oakland University, Rochester, MI, USA. | en_US |
dc.contributor.affiliationother | Department of Chemistry and Institute of Biotechnology, Oakland University, Rochester, MI, USA. | en_US |
dc.identifier.pmid | 8166690 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31635/1/0000569.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/bbrc.1994.1436 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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