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Lipid peroxidation in the adrenal glands of male rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

dc.contributor.authorBestervelt, Lorelle L.en_US
dc.contributor.authorPiper, Douglas W.en_US
dc.contributor.authorPitt, Jeff A.en_US
dc.contributor.authorPiper, Walter N.en_US
dc.date.accessioned2006-04-10T18:21:57Z
dc.date.available2006-04-10T18:21:57Z
dc.date.issued1994-02-01en_US
dc.identifier.citationBestervelt, Lorelle L., Piper, Douglas W., Pitt, Jeff A., Piper, Walter N. (1994/02/01)."Lipid peroxidation in the adrenal glands of male rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)." Toxicology Letters 70(2): 139-145. <http://hdl.handle.net/2027.42/31799>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TCR-477Y251-1XD/2/f62d61279b66d584dccd79476d8931a5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31799
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8296318&dopt=citationen_US
dc.description.abstractThis study was performed to determine whether TCDD (50 [mu]g/kg; single oral dose) could induce adrenal microsomal lipid peroxidation, which might be correlated to decreased levels of cytochrome P-450 and 21-hydroxylase activity. The amount of malondialdehyde (MDA) formed was significantly higher than controls at days 1 through 5 following TCDD treatment. Microsomal cytochrome P-450 levels were depressed after lipid peroxidation at days 1, 3, and 5, and 21-hydroxylase activity decreased at day 5 after TCDD treatment. This study shows that TCDD stimulates adrenal microsomal lipid peroxidation which is associated with decreased cytochrome P-450 levels and 21-hydroxylase activity.en_US
dc.format.extent513003 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleLipid peroxidation in the adrenal glands of male rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, Ann Arbor, MI, USAen_US
dc.identifier.pmid8296318en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31799/1/0000743.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-4274(94)90157-0en_US
dc.identifier.sourceToxicology Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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