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Corticotropin releasing hormone is involved in exercise-induced elevation in core temperature

dc.contributor.authorRowsey, Pamela Johnsonen_US
dc.contributor.authorKluger, Matthew J.en_US
dc.date.accessioned2006-04-10T18:27:28Z
dc.date.available2006-04-10T18:27:28Z
dc.date.issued1994en_US
dc.identifier.citationRowsey, Pamela Johnson, Kluger, Matthew J. (1994)."Corticotropin releasing hormone is involved in exercise-induced elevation in core temperature." Psychoneuroendocrinology 19(2): 179-187. <http://hdl.handle.net/2027.42/31899>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TBX-4859R9C-2C/2/722e3dd5f1a62ca6b3c425ad5c3477b5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31899
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8190837&dopt=citationen_US
dc.description.abstractTo determine the involvement of corticotropin releasing factor (CRF) in exercise-induced elevation in core temperature of female rats, CRF antibody or vehicle was injected intracerebroventricularly (ICV) into rats that had free access to exercise wheels for 6 weeks. On the day of injection, there were no differences in body temperature or activity following these injections. However, exercising animals had a significantly attenuated daytime temperature when compared to vehicle control animals at one day postinjection with the CRF antibody. Although these animals have significantly lower body temperature than the animals that received vehicle, the injection of CRF antibody had no effect on locomotor activity. Therefore, this decrease in temperature is not due to a reduction in activity. These results suggest that CRF is involved in the exercise-induced elevation in daytime body temperature. Since the antibody also attenuates fevers caused by IL-1[beta] (and presumably other cytokines), it is possible that the daytime elevation in body temperature of exercising rats is mediated by IL-1[beta] other cytokines.en_US
dc.format.extent578113 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCorticotropin releasing hormone is involved in exercise-induced elevation in core temperatureen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Kinesiology, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid8190837en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31899/1/0000852.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0306-4530(94)90007-8en_US
dc.identifier.sourcePsychoneuroendocrinologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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