Isotopic tracer studies on the biosynthesis of deoxyribose in the rat

Ghosh, Dolly; Bernstein, Isadore A.

1963

Citation: Ghosh, Dolly, Bernstein, I. A. (1963)."Isotopic tracer studies on the biosynthesis of deoxyribose in the rat." Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects 72(): 1-9. <http://hdl.handle.net/2027.42/32242>

Abstract: The biosynthesis of deoxyribose, in vivo, was studied with NaH14CO3 as a tracer, in normal adult, starved adult, normal newborn, "thiamine-deficient" adult and "tumor bearing" rats and in Yoshida ascites-tumor cells. Comparisons of the tracer patterns in ribose and deoxyribose isolated from the nucleic acids of skin and liver suggest that in young tissues the formation of deoxyribose may occur by direct reduction from ribose or via an intermediate common to ribose. The data obtained from ribose which is the precursor of deoxyribose, is different from that of the ribose isolated from the RNA. The presence of an ascitic tumor in the young adult seems to influence pentose metabolism in the host liver.

DOIs: http://dx.doi.org/10.1016/0926-6550(63)90302-5

PMID: 13947520

URI: http://www.sciencedirect.com/science/article/B73G7-487F7DH-3K/2/5a08b1adeeaf26f9065fb0f1c33ebcf7
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=13947520&dopt=citation

Handle: http://hdl.handle.net/2027.42/32242

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