Variation in the primary structure of carbonic anhydrase B in man, great apes, and old world monkeys

Abstract

The amino acid compositions and sequences of 15 homologous tryptic peptides of carbonic anhydrase B from man and 7 Old World primates were compared. Of the 133 residues examined, differences were noted at 8 presumably homologous sites. Chimpanzee and man differed at only one site, whereas orangutan and man differed at four sites. The four monkey species differed from man by four to 6 residues. The fixation rates for mutations of these carbonic anhydrases appear to be similar to those found for the hemoglobin chains of the same species.