The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene
dc.contributor.author | Baron, Jennifer | en_US |
dc.contributor.author | Tephly, T. R. | en_US |
dc.date.accessioned | 2006-04-17T15:17:30Z | |
dc.date.available | 2006-04-17T15:17:30Z | |
dc.date.issued | 1969-08-15 | en_US |
dc.identifier.citation | Baron, J., Tephly, T. R. (1969/08/15)."The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene." Biochemical and Biophysical Research Communications 36(4): 526-532. <http://hdl.handle.net/2027.42/32915> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4F02W3B-R/2/710281d4cb3dcd9405fe4d3d055f3af8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/32915 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4390185&dopt=citation | en_US |
dc.description.abstract | [delta]-Aminolevulinic acid synthetase, the initial and rate limiting step in hepatic heme synthesis, is induced by both benzpyrene and phenobarbital. Induction of this enzyme by benzpyrene results in the stimulation of glycine-2-14C incorporation into hepatic microsomal heme in vivo and in the induction of cytochrome P-450 and N-demethylase activity. 3-Amino-1,2,4-triazole, an inhibitor of the second step in hepatic heme synthesis, prevents the stimulation of hepatic heme synthesis and the induction of P-450 and N-demethylase activity. It is suggested that induction of [delta]-aminolevulinic acid synthetase leading to increases in hepatic heme synthesis may be the mechanism by which benzpyrene induces cytochrome P-450 and certain hepatic microsomal oxidations. | en_US |
dc.format.extent | 349252 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48104, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48104, USA | en_US |
dc.identifier.pmid | 4390185 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/32915/1/0000295.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(69)90336-2 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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