Ldh isoenzymes by urea inhibition and substrate (lactate) modification: a clinical evaluation
dc.contributor.author | Batsakis, John G. | en_US |
dc.contributor.author | Briere, Russell O. | en_US |
dc.date.accessioned | 2006-04-17T15:27:11Z | |
dc.date.available | 2006-04-17T15:27:11Z | |
dc.date.issued | 1968-08 | en_US |
dc.identifier.citation | Batsakis, John G.; Briere, Russell O. (1968/08)."Ldh isoenzymes by urea inhibition and substrate (lactate) modification: a clinical evaluation." Clinical Biochemistry 2(): 171-176. <http://hdl.handle.net/2027.42/33128> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TDD-4GMBG9W-N/2/afa499e2435dc4e2df63c81afa51d91f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33128 | |
dc.description.abstract | Summary1. Differentiation of the anodic (LDH1 and LDH2) and cathodic (LDH5) isoenzymes of lactate dehydrogenase in human sera can be accomplished by combining variable substrate (lactate or pyruvate) concentrations with specific inhibitors such as urea.2. One technic useful in the clinical laboratory is based upon a colorimetric assay for total LDH activity in which the oxidation of lactate is coupled to the reduction of a tetrazolium salt. The ratios of activity in 2M lactate to the activity in 0.02 lactate--2M urea yields an index of the predominant LDH isoenzymes in sera.3. Clear-cut distinction between myocardial and hepatic isoenzyme predominance was achieved in the majority of 98 patients studied, but the isoenzyme index can be misleading and non-confirmatory in patients who have liberation of LDH isoenzymes from several organ sources.4. The LDH isoenzyme index is considered to be an additional and informative test only and cannot serve as a diagnostic estimation. | en_US |
dc.format.extent | 331350 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Ldh isoenzymes by urea inhibition and substrate (lactate) modification: a clinical evaluation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | The Johnston- Willis Hospital, Richmond, Virginia,UK | en_US |
dc.contributor.affiliationother | The Johnston- Willis Hospital, Richmond, Virginia,UK | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33128/1/0000514.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0009-9120(68)80074-8 | en_US |
dc.identifier.source | Clinical Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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