Mutations of phage P22 affecting phage DNA synthesis and lysogenization
dc.contributor.author | Levine, Myron | en_US |
dc.contributor.author | Schott, Carol | en_US |
dc.date.accessioned | 2006-04-17T16:20:54Z | |
dc.date.available | 2006-04-17T16:20:54Z | |
dc.date.issued | 1971-11-28 | en_US |
dc.identifier.citation | Levine, Myron, Schott, Carol (1971/11/28)."Mutations of phage P22 affecting phage DNA synthesis and lysogenization." Journal of Molecular Biology 62(1): 53-64. <http://hdl.handle.net/2027.42/33527> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WK7-4DPKV3S-VD/2/d89058cbeeb9c151fc2e045efe72238d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33527 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4945536&dopt=citation | en_US |
dc.description.abstract | Two temperature-sensitive mutants of phage P22, ts18.1 and ts12.1, are described which have recessive DNA-negative phenotypes. At high temperature they fail to synthesize phage DNA. In mixed infection with the two mutants or either mutant and wild-type phage, DNA synthesis and phage production are normal. In addition, under non-permissive conditions, these mutants fail to lysogenize and show dominant integration-negative phenotypes. They do not complement for lysogenization in mixed infection and each of these mutants interferes with lysogenization by wild type. At low temperature each mutant shows normal phage production and normal frequencies of lysogenization. These mutant lysogens are stable at high temperature. The data suggest the requirement for common functions for genome replication and prophage integration. The mutations are closely linked and map just to the right of the c region in map positions analogous to genes O and P of phage [lambda]. | en_US |
dc.format.extent | 880563 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mutations of phage P22 affecting phage DNA synthesis and lysogenization | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.identifier.pmid | 4945536 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33527/1/0000025.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-2836(71)90130-6 | en_US |
dc.identifier.source | Journal of Molecular Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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