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Mathematical analysis and digital simulation of the control of erythropoiesis

dc.contributor.authorMylrea, Kenneth C.en_US
dc.contributor.authorAbbrecht, Peter Hermanen_US
dc.date.accessioned2006-04-17T16:21:33Z
dc.date.available2006-04-17T16:21:33Z
dc.date.issued1971-11en_US
dc.identifier.citationMylrea, Kenneth C., Abbrecht, Peter H. (1971/11)."Mathematical analysis and digital simulation of the control of erythropoiesis." Journal of Theoretical Biology 33(2): 279-297. <http://hdl.handle.net/2027.42/33539>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WMD-4F1J831-H0/2/f2e5ed73f26c04f4fa2bd67394d2280aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33539
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5135919&dopt=citationen_US
dc.description.abstractA mathematical model is presented which represents the control system for erythropoiesis. In the model, it is postulated that the rate of erythropoiesis is controlled by a hormone, erythropoietin, which is released from the kidney in response to reduced renal oxygen supply. Equations are developed which relate erythropoietin release to arterial oxyhemoglobin concentration, and hemoglobin production to plasma erythropoietin concentration, with appropriate time delays. Effects of changes in plasma volume during hypoxia are included. The model is used with a digital computer to simulate the dynamic response of the erythropoietic system to a step decrease in the pO2 of inspired air. The response of the model compares favorably with experimental data obtained from mice subjected to different degrees of hypoxia.en_US
dc.format.extent1081602 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMathematical analysis and digital simulation of the control of erythropoiesisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology and Bioengineering Program, University of Michigan, School of Medicine, Ann Arbor, Mich. 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of Physiology and Bioengineering Program, University of Michigan, School of Medicine, Ann Arbor, Mich. 48104, U.S.A.en_US
dc.identifier.pmid5135919en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33539/1/0000038.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-5193(71)90067-1en_US
dc.identifier.sourceJournal of Theoretical Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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