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The uptake of pentazocine into brain
dc.contributor.authorMedzihradsky, Fedoren_US
dc.contributor.authorAhmad, K.en_US
dc.date.accessioned2006-04-17T16:25:52Z
dc.date.available2006-04-17T16:25:52Z
dc.date.issued1971-06-15en_US
dc.identifier.citationMedzihradsky, F., Ahmad, K. (1971/06/15)."The uptake of pentazocine into brain." Life Sciences 10(12, Part 1): 711-720. <http://hdl.handle.net/2027.42/33633>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-4754818-99/2/8ba78055ef0564ee440ba083636c3cbden_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33633
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5556759&dopt=citationen_US
dc.description.abstractA simple procedure for the extraction from tissues and determination by gas chromatography of pentazocine was developed. The mean recovery from brain was 96%.The time- and dose-dependent uptake of pentazocine into the brain was investigated and correlated with the plasma levels of the drug. The results showed a rapid entry of pentazocine into the drug. The results showed a rapid entry of pentazocine into at 2 min and 10 min, respectively, after the i.p. administration. After the injection of a single dose, the ratio, concentration of pentazocine in plasma/concentration of pentazocine in brain was constant from 10-90 min. This ratio remained unchanged over the range of 25-100 mg/kg of administered drug.en_US
dc.format.extent323565 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe uptake of pentazocine into brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Biological Chemistry and Pharmacology and Upjohn Center for Clinical Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartments of Biological Chemistry and Pharmacology and Upjohn Center for Clinical Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.identifier.pmid5556759en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33633/1/0000141.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(71)90015-4en_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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