Role of 3',5'-cyclic AMP in the control of nuclear protein kinase activity
dc.contributor.author | Rikans, Lora E. | en_US |
dc.contributor.author | Ruddoh, Raymond W. | en_US |
dc.date.accessioned | 2006-04-17T16:36:13Z | |
dc.date.available | 2006-04-17T16:36:13Z | |
dc.date.issued | 1973-09-05 | en_US |
dc.identifier.citation | Rikans, Lora E., Ruddoh, Raymond W. (1973/09/05)."Role of 3',5'-cyclic AMP in the control of nuclear protein kinase activity." Biochemical and Biophysical Research Communications 54(1): 387-394. <http://hdl.handle.net/2027.42/33814> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DW335R-65/2/5499039d0ce62e2b7272759bf0616713 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33814 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4354947&dopt=citation | en_US |
dc.description.abstract | The role of cAMP in the regulation of nuclear protein kinase activity was investigated. Acidic nuclear proteins prepared from rat liver nuclei were separated by phosphocellulose chromatography into four peaks of protein kinase activity and two peaks of cAMP-binding activity. A fraction which bound cAMP also inhibited the most active nuclear protein kinase, K IV, and the inhibition was diminished in the presence of 5 [mu]M cAMP. Further support for the regulation of nuclear kinases by cAMP was obtained using a regulatory subunit prepared from rabbit muscle protein kinase. The muscle regulatory subunit markedly inhibited liver nuclear kinase activities. The addition of cAMP partially restored the activities. | en_US |
dc.format.extent | 449716 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Role of 3',5'-cyclic AMP in the control of nuclear protein kinase activity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48104, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48104, USA | en_US |
dc.identifier.pmid | 4354947 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33814/1/0000070.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(73)90934-0 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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