Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management
dc.contributor.author | Hansson, Lennart | en_US |
dc.contributor.author | Hunyor, Stephen N. | en_US |
dc.contributor.author | Julius, Stevo | en_US |
dc.contributor.author | Hoobler, Sibley W. | en_US |
dc.date.accessioned | 2006-04-17T16:39:42Z | |
dc.date.available | 2006-04-17T16:39:42Z | |
dc.date.issued | 1973-05 | en_US |
dc.identifier.citation | Hansson, L., Hunyor, S. N., Julius, S., Hoobler, S. W. (1973/05)."Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management." American Heart Journal 85(5): 605-610. <http://hdl.handle.net/2027.42/33890> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BT99MJ-FY/2/c1b9daa70a7bc044360a6fb9115f684c | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33890 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4697628&dopt=citation | en_US |
dc.description.abstract | In five patients with severe essential hypertension, placebo was substituted after 24 to 48 months of treatment with clonidine and a diuretic. In the present study, four of the patients developed a marked blood pressure rise following withdrawal of clonidine which was rapidly reversed by intravenous administration of propranolol 0.2 mg. per kilogram of body weight and phentolamine 20 to 30 mg. The fifth patient was pretreated with reserpine 2.0 mg. intramuscularly for three days prior to withdrawal of clonidine, and the blood pressure rise which he experienced was far less impressive. All patients experienced similar "withdrawal" symptoms, consisting of headaches, insomnia, restlessness, tremor, and nausea.Catecholamines were determined in arterial blood and urine, before and during the overshoot. They revealed a marked increase, particularly in the urine samples, consistent with the appearance of a hyperadrenergic state. | en_US |
dc.format.extent | 483032 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 4697628 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33890/1/0000155.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(73)90165-8 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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