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Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management

dc.contributor.authorHansson, Lennarten_US
dc.contributor.authorHunyor, Stephen N.en_US
dc.contributor.authorJulius, Stevoen_US
dc.contributor.authorHoobler, Sibley W.en_US
dc.date.accessioned2006-04-17T16:39:42Z
dc.date.available2006-04-17T16:39:42Z
dc.date.issued1973-05en_US
dc.identifier.citationHansson, L., Hunyor, S. N., Julius, S., Hoobler, S. W. (1973/05)."Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management." American Heart Journal 85(5): 605-610. <http://hdl.handle.net/2027.42/33890>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6W9H-4BT99MJ-FY/2/c1b9daa70a7bc044360a6fb9115f684cen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33890
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4697628&dopt=citationen_US
dc.description.abstractIn five patients with severe essential hypertension, placebo was substituted after 24 to 48 months of treatment with clonidine and a diuretic. In the present study, four of the patients developed a marked blood pressure rise following withdrawal of clonidine which was rapidly reversed by intravenous administration of propranolol 0.2 mg. per kilogram of body weight and phentolamine 20 to 30 mg. The fifth patient was pretreated with reserpine 2.0 mg. intramuscularly for three days prior to withdrawal of clonidine, and the blood pressure rise which he experienced was far less impressive. All patients experienced similar "withdrawal" symptoms, consisting of headaches, insomnia, restlessness, tremor, and nausea.Catecholamines were determined in arterial blood and urine, before and during the overshoot. They revealed a marked increase, particularly in the urine samples, consistent with the appearance of a hyperadrenergic state.en_US
dc.format.extent483032 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBlood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute managementen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Mich., USAen_US
dc.identifier.pmid4697628en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33890/1/0000155.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0002-8703(73)90165-8en_US
dc.identifier.sourceAmerican Heart Journalen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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