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Can true papillary neoplasms of breast and their mimickers be accurately classified by cytology?

dc.contributor.authorMichael, Claire W.en_US
dc.contributor.authorBuschmann, Bruceen_US
dc.date.accessioned2006-04-19T13:30:56Z
dc.date.available2006-04-19T13:30:56Z
dc.date.issued2002-04-25en_US
dc.identifier.citationMichael, Claire W.; Buschmann, Bruce (2002)."Can true papillary neoplasms of breast and their mimickers be accurately classified by cytology?." Cancer 96(2): 92-100. <http://hdl.handle.net/2027.42/34364>en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.issn1097-0142en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/34364
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11954026&dopt=citationen_US
dc.description.abstractBACKGROUND The cytologic accuracy in assessing malignancy in papillary breast neoplasms (PBNs) is controversial. This is further complicated by overlapping features observed in other breast lesions that produce papillary-like tissue fragments. METHODS The authors reviewed 22 fine-needle aspirates (FNAs) from histologically proven papillary neoplasms: papillary carcinoma (PCA; 10 aspirates) and intraductal papilloma (IDP; 12 aspirates). They also reviewed 8 FNAs in which a papillary neoplasm was suggested by cytology but not confirmed by follow-up biopsy: fibroadenoma (6), mucinous carcinoma (1), and cribriform ductal carcinoma in situ (1). RESULTS Papillary carcinoma can be distinguished from IDP by the higher cellularity, more complex papillae with thin disorganized fronds, mild to moderate nuclear atypia, and prominent dissociation with many single papillae. Fibrovascular cores (FVCs) were more common in PCA than IDP in which detached fibrous tissue fragments were frequently seen. Atypical IDP exhibited features intermediate between PCA and IDP. Apocrine metaplasia was variably present in IDP, atypical IDP, and fibroadenoma but absent in all carcinomas. Intraductal papilloma can be distinguished from fibroadenoma by their broad ruffled branches, scalloped borders, and tiny tongue-like projections. True papillae were commonly covered by tall columnar cells. Myoepithelial cells were few in IDP but were numerous in fibroadenoma. The epithelial fragments in nonpapillary lesions presented as cellular spheres and/or complex sheets with finger-like projections but lacked FVCs and columnar cells. CONCLUSIONS Papillary breast neoplasms can be accurately classified by cytology. Closer evaluation of the tissue fragments architecture and the background can help in separating PBN from their mimics. Cancer (Cancer Cytopathol) 2002;96:000–000. © 2002 American Cancer Society.en_US
dc.format.extent3789420 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleCan true papillary neoplasms of breast and their mimickers be accurately classified by cytology?en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Department of Pathology, Ann Arbor, Michigan ; Fax: (734) 763-4095 ; University of Michigan, Department of Pathology, 1500 E. Medical Center Drive, Room 2G332, Box 0054, Ann Arbor, MI 48105en_US
dc.contributor.affiliationotherUniversity of South Alabama, Department of Pathology, Mobile, Alabamaen_US
dc.identifier.pmid11954026en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/34364/1/10481_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cncr.10481en_US
dc.identifier.sourceCanceren_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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