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Dysplasia in Barrett esophagus

dc.contributor.authorLao, Christopher D.en_US
dc.contributor.authorSimmons, Melanieen_US
dc.contributor.authorSyngal, Sapnaen_US
dc.contributor.authorBresalier, Robert S.en_US
dc.contributor.authorFortlage, Laurieen_US
dc.contributor.authorNormolle, Daniel P.en_US
dc.contributor.authorGriffith, Kent A.en_US
dc.contributor.authorAppelman, Henry D.en_US
dc.contributor.authorBrenner, Dean E.en_US
dc.date.accessioned2006-04-19T13:32:00Z
dc.date.available2006-04-19T13:32:00Z
dc.date.issued2004-04-15en_US
dc.identifier.citationLao, Christopher D.; Simmons, Melanie; Syngal, Sapna; Bresalier, Robert S.; Fortlage, Laurie; Normolle, Daniel; Griffith, Kent A.; Appelman, Henry D.; Brenner, Dean E. (2004)."Dysplasia in Barrett esophagus." Cancer 100(8): 1622-1627. <http://hdl.handle.net/2027.42/34387>en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.issn1097-0142en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/34387
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15073848&dopt=citationen_US
dc.description.abstractBACKGROUND Dysplasia in Barrett esophagus is a premalignant condition that is associated with an increased risk of developing esophageal adenocarcinoma. Unfortunately, clinical investigation aimed at prevention of progression to malignant disease has been hampered by the variable prevalence of dysplasia reported in the literature. The objective of the current study was to more accurately determine the prevalence of dysplasia among individuals with Barrett esophagus who would be available for enrollment in a chemoprevention trial. METHODS The pathology archives of 3 institutions were reviewed over a 5-year period for all reports of diagnoses of Barrett esophagus. Surgical cases, malignancies, and duplicate or referral cases were excluded from the analysis. RESULTS A total of 790 cases of Barrett esophagus were identified. Of these, 37 (4.7%) were cases of low-grade dysplasia (LGD), and 20 (2.5%) were cases of high-grade dysplasia. The University of Michigan Medical Center (Ann Arbor, MI) diagnosed 18 cases of LGD, Henry Ford Hospital (Detroit, MI) diagnosed 15 cases of LGD, and Brigham and Women's Hospital (Boston, MA) diagnosed 4 cases of LGD in patients with Barrett esophagus over the 5-year study period. CONCLUSIONS The confirmed low prevalence of cases of LGD will affect the design of future clinical trials of chemopreventive interventions for Barrett esophagus. Cancer 2004. © 2004 American Cancer Society.en_US
dc.format.extent82884 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleDysplasia in Barrett esophagusen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Biostatistics, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan ; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan ; Fax: (734) 647-9817 ; 2150 Cancer Center and Geriatrics Center, University of Michigan Medical Center, Ann Arbor, MI 48109-0930en_US
dc.contributor.affiliationotherDana-Farber/Brigham and Women's Cancer Center, Boston, Massachusettsen_US
dc.contributor.affiliationotherDivision of Gastroenterology, Henry Ford Medical Center, Detroit, Michiganen_US
dc.identifier.pmid15073848en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/34387/1/20149_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cncr.20149en_US
dc.identifier.sourceCanceren_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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