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Synthetic nano-fibrillar extracellular matrices with predesigned macroporous architectures

dc.contributor.authorZhang, Ruiyunen_US
dc.contributor.authorMa, Peter X.en_US
dc.date.accessioned2006-04-19T13:33:25Z
dc.date.available2006-04-19T13:33:25Z
dc.date.issued2000-11en_US
dc.identifier.citationZhang, Ruiyun; Ma, Peter X. (2000)."Synthetic nano-fibrillar extracellular matrices with predesigned macroporous architectures." Journal of Biomedical Materials Research 52(2): 430-438. <http://hdl.handle.net/2027.42/34418>en_US
dc.identifier.issn0021-9304en_US
dc.identifier.issn1097-4636en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/34418
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10951385&dopt=citationen_US
dc.description.abstractScaffolding plays a pivotal role in tissue engineering. To mimic the architecture of a natural extracellular matrix component—collagen, nona-fibrous matrices have been created with synthetic biodegradable polymers in our laboratory using a phase-separation technique. To improve the cell seeding, distribution, mass transport, and new tissue organization, three-dimensional macroporous architectures are built in the nano-fibrous matrices. Water-soluble porogen materials are first fabricated into three-dimensional negative replicas of the desired macroporous architectures. Polymer solutions are then cast over the porogen assemblies in a mold, and are thermally phase-separated to form nano-fibrous matrices. The porogen materials are leached out with water to finally form the synthetic nano-fibrous extracellular matrices with predesigned macroporous architectures. In this way, synthetic polymer matrices are created with architectural features at several levels, including the anatomical shape of the matrix, macroporous elements (100 Μm to millimeters), interfiber distance (microns), and the diameter of the fibers (50–500 nm). These scaffolding materials circumvent the concerns of pathogen transmission and immuno-rejection associated with natural collagen. With the flexibility in the design of chemical structure, molecular weight, architecture, degradation rate, and mechanical properties, these novel synthetic matrices may serve as superior scaffolding for tissue engineering. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 430–438, 2000.en_US
dc.format.extent844686 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subject.otherChemistryen_US
dc.subject.otherPolymer and Materials Scienceen_US
dc.titleSynthetic nano-fibrillar extracellular matrices with predesigned macroporous architecturesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelBiomedical Engineeringen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, 1011 North University Avenue, Room 2211, The University of Michigan, Ann Arbor, Michigan 48109-1078en_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, 1011 North University Avenue, Room 2211, The University of Michigan, Ann Arbor, Michigan 48109-1078 ; Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109-1078 ; Macromolecular Science and Engineering Center, The University of Michigan, Ann Arbor, Michigan 48109-1078 ; Department of Biologic and Materials Sciences, 1011 North University Avenue, Room 2211, The University of Michigan, Ann Arbor, Michigan 48109-1078en_US
dc.identifier.pmid10951385en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/34418/1/25_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/1097-4636(200011)52:2<430::AID-JBM25>3.0.CO;2-Len_US
dc.identifier.sourceJournal of Biomedical Materials Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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