Engineering vascular networks in porous polymer matrices
dc.contributor.author | Peters, Martin C. | en_US |
dc.contributor.author | Polverini, Peter J. | en_US |
dc.contributor.author | Mooney, David J. | en_US |
dc.date.accessioned | 2006-04-19T13:33:46Z | |
dc.date.available | 2006-04-19T13:33:46Z | |
dc.date.issued | 2002-06-15 | en_US |
dc.identifier.citation | Peters, Martin C.; Polverini, Peter J.; Mooney, David J. (2002)."Engineering vascular networks in porous polymer matrices." Journal of Biomedical Materials Research 60(4): 668-678. <http://hdl.handle.net/2027.42/34425> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34425 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11948526&dopt=citation | en_US |
dc.description.abstract | Enhanced vascularization is critical to the treatment of ischemic tissues and the engineering of new tissues and organs. We have investigated whether sustained and localized delivery of vascular endothelial growth factor (VEGF) combined with transplantation of human microvascular endothelial cells (HMVECs) can be used to engineer new vascular networks. VEGF was incorporated and released in a sustained manner from porous poly(lactic- co -glycolic acid) (PLG) matrices to promote angiogenesis at the transplantation site. VEGF could be incorporated and released in a biologically active form from PLG matrices, with the majority of VEGF release (64%) occurring within 2 weeks. These matrices promoted a 260% increase in the density of host SCID mouse-derived capillaries invading the matrices after 7 days of implantation, confirming the activity of the released VEGF. HMVECs were transplanted into SCID mice on PLG matrices, and organized to form immature human-derived vessels within 3 days. Functional vessels were observed within 7 days. Importantly, when HMVECs were transplanted on VEGF-releasing matrices, a 160% increase in the density of human-derived blood vessels was observed after 14 days. These findings suggest that combining elements of vasculogenesis and angiogenesis provides a viable and novel approach to enhancing local vascularization. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 668–678, 2002 | en_US |
dc.format.extent | 7787552 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Engineering vascular networks in porous polymer matrices | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, 5213 Dental School, 1011 North University Avenue, Ann Arbor, Michigan 48109-1078 | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, 5213 Dental School, 1011 North University Avenue, Ann Arbor, Michigan 48109-1078 ; Department of Biologic & Materials Sciences, University of Michigan, 5213 Dental School, 1011 North University Avenue, Ann Arbor, Michigan 48109-1078 ; Department of Chemical Engineering, University of Michigan, 5213 Dental School, 1011 North University Avenue, Ann Arbor, Michigan 48109-1078 ; Department of Biomedical Engineering, University of Michigan, 5213 Dental School, 1011 North University Avenue, Ann Arbor, Michigan 48109-1078 | en_US |
dc.contributor.affiliationother | Dental School, University of Minnesota, Minneapolis, Minnesota 55455 | en_US |
dc.identifier.pmid | 11948526 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34425/1/10134_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.10134 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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