Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization
dc.contributor.author | Chen, Pen-Chung | en_US |
dc.contributor.author | Park, Yoon Jeong | en_US |
dc.contributor.author | Chang, Li-Chien | en_US |
dc.contributor.author | Kohane, Daniel S. | en_US |
dc.contributor.author | Bartlett, Robert H. | en_US |
dc.contributor.author | Langer, Robert S. | en_US |
dc.contributor.author | Yang, Victor C. | en_US |
dc.date.accessioned | 2006-04-19T13:34:11Z | |
dc.date.available | 2006-04-19T13:34:11Z | |
dc.date.issued | 2004-09-01 | en_US |
dc.identifier.citation | Chen, Pen-Chung; Park, Yoon Jeong; Chang, Li-Chien; Kohane, Daniel S.; Bartlett, Robert H.; Langer, Robert; Yang, Victor C. (2004)."Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization." Journal of Biomedical Materials Research 70A(3): 412-419. <http://hdl.handle.net/2027.42/34434> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34434 | |
dc.description.abstract | Current treatment protocol for postoperative pain is to infuse anesthetic solution around nerves or into the epidural space. This clinical practice is beset by the short duration of the anesthetic effect unless the infusion is continuous. Continuous infusion, however, requires hospitalization of the patients, thereby increasing medical costs. In addition, it also causes systemic accumulation of the drug. We reported herein a novel treatment for the postoperative pain by applying to the surgical site a biodegradable microsphere-gel system for prolonged and localized release of encapsulated anesthetic drugs. This lidocaine-containing biodegradable poly( D , L -lactic acid) (PLA) microsphere system, although being established previously by other investigators, was hindered by a burst release and a followed rapid release of the drug within several hours in vitro . In this article, we demonstrated that by a step-by-step modification of the formulation, prolonged release of lidocaine, up to several days in vitro , could be achieved. Differential scanning calorimetry revealed a lower glass transition temperature for these lidocaine-loaded microspheres comparing to that of lidocaine-free microspheres. This decreased T g explained for the tendency of the lidocaine-loaded microspheres to physically fuse at higher temperatures. In vitro studies showed that microspheres, when loaded with 35% lidocaine, yielded a threefold increase in the degradation rate. The molecular weight of PLA of the drug-loaded microspheres was reduced by 50% within a period of 1 month. Based on the results (of prolonged lidocaine release and rapid PLA microsphere degradation), this lidocaine-loaded PLA microsphere system could offer a simple solution to the treatment of postoperative pain. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 412–419, 2004 | en_US |
dc.format.extent | 365523 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Albert B. Prescott Professor of Pharmaceutical Science, College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationum | School of Medicine, The University of Michigan, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationum | Albert B. Prescott Professor of Pharmaceutical Science, College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 ; Albert B. Prescott Professor of Pharmaceutical Science, College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationother | College of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-ku, Seoul 110-749, Korea | en_US |
dc.contributor.affiliationother | School of Pharmacy, National Defense Medical Center, 161 MinChun E. Road, Sec. 6, Taipei, Taiwan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114 ; Department of Chemical Engineering, 16-343 Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 | en_US |
dc.contributor.affiliationother | Department of Chemical Engineering, 16-343 Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34434/1/30086_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.a.30086 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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