Geometric morphometrics of corpus callosum and subcortical structures in the fetal-alcohol-affected brain
dc.contributor.author | Bookstein, Fred L. | en_US |
dc.contributor.author | Sampson, Paul D. | en_US |
dc.contributor.author | Streissguth, Ann P. | en_US |
dc.contributor.author | Connor, Paul D. | en_US |
dc.date.accessioned | 2006-04-19T13:39:47Z | |
dc.date.available | 2006-04-19T13:39:47Z | |
dc.date.issued | 2001-07 | en_US |
dc.identifier.citation | Bookstein, Fred L.; Sampson, Paul D.; Streissguth, Ann P.; Connor, Paul D. (2001)."Geometric morphometrics of corpus callosum and subcortical structures in the fetal-alcohol-affected brain." Teratology 64(1): 4-32. <http://hdl.handle.net/2027.42/34556> | en_US |
dc.identifier.issn | 0040-3709 | en_US |
dc.identifier.issn | 1096-9926 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34556 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11410908&dopt=citation | en_US |
dc.description.abstract | Background Although experienced clinicians have been diagnosing fetal alcohol syndrome (FAS) for nearly 30 years, the rest of the spectrum of fetal alcohol damage is not being classified effectively. This article describes a quantification of neuroanatomical structure that may supply a useful discriminator of prenatal brain damage from alcohol. It is demonstrated in a data set of adults of both sexes. Methods Ninety adults (45 males) were examined by magnetic resonance imaging (MRI). These subjects were group-matched for age and ethnicity across three diagnoses: FAS, fetal alcohol effects (FAE), and normals. All FAS and FAE were heavily alcohol-exposed in utero; normals were not. From T 1 -weighted MR brain images, we extracted 3D morphometric representations of shape for 33-landmark point configurations and 40-point outlines of the corpus callosum along its midline (a slightly nonplanar structure). Results There are striking differences between exposed and unexposed in the statistical distributions of these two shapes. The differences are better characterized by excess variance in the exposed group than by any change in average landmark or outline shape. For each sex, combining the callosal outline data with the landmark data leads to a powerful quadratic discriminator of exposed from unexposed. The discriminating features include the relationship of brain stem to diencephalon, and localized variabilities of callosal outline shape, but not diagnosis (FAS vs. FAE). Conclusions Statistical analysis of brain shape is a powerful new source of information relevant to fetal alcohol spectrum nosology and etiology. Patients with FAS and FAE do not differ in these brain shape features, but both differ from the unexposed. The aspects of brain shape that are especially variable may be entailed in the underlying neuroteratogenetic mechanisms. Teratology 64:4–32, 2001. © 2001 Wiley-Liss, Inc. | en_US |
dc.format.extent | 706918 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Geometric morphometrics of corpus callosum and subcortical structures in the fetal-alcohol-affected brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109 ; Institute of Gerontology, University of Michigan, 300 North Ingalls Building, Ann Arbor, MI 48109-2007 | en_US |
dc.contributor.affiliationother | Department of Statistics, University of Washington, Seattle, Washington 98195 | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195 | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195 | en_US |
dc.identifier.pmid | 11410908 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34556/1/1044_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/tera.1044 | en_US |
dc.identifier.source | Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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