Turner Syndrome morphology and morphometrics: Cardiac hypoplasia as a cause of midgestation death
dc.contributor.author | Barr, Mason | en_US |
dc.contributor.author | Oman-Ganes, Loraine | en_US |
dc.date.accessioned | 2006-04-19T13:39:52Z | |
dc.date.available | 2006-04-19T13:39:52Z | |
dc.date.issued | 2002-08 | en_US |
dc.identifier.citation | Barr, Mason; Oman-Ganes, Loraine (2002)."Turner Syndrome morphology and morphometrics: Cardiac hypoplasia as a cause of midgestation death." Teratology 66(2): 65-72. <http://hdl.handle.net/2027.42/34558> | en_US |
dc.identifier.issn | 0040-3709 | en_US |
dc.identifier.issn | 1096-9926 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34558 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12210009&dopt=citation | en_US |
dc.description.abstract | Background A female fetus with massive truncal-limb hydrops and large, loculated, nuchal hygromas in midgestation is highly likely to have Turner syndrome. This phenotype is recognized to be usually lethal, with only more mildly affected fetuses surviving to term birth. Methods The morphology and morphometrics of 117 midgestation fetuses with phenotypic Turner syndrome were analyzed. Results More than 90% of fetuses with phenotypic Turner syndrome were found to have heart weights below the 2.5 centile, as well as lung hypoplasia and restricted limb growth for brain weight standards, although brain weight was only mildly reduced for gestational age. In contrast, subnormal heart weight was much less common among fetuses with other etiologies of hydrops, hygromas, or pleural effusions. Conclusions We hypothesize that myocardial hypoplasia is a primary defect in Turner syndrome, and it leads to or is a major contributor to the phenotypic features that end in midgestational death. Teratology 66:65–72, 2002. © 2002 Wiley-Liss, Inc. | en_US |
dc.format.extent | 479084 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Turner Syndrome morphology and morphometrics: Cardiac hypoplasia as a cause of midgestation death | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Teratology Unit, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 ; Teratology Unit, Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 ; Teratology Unit, Department of Obstetrics, University of Michigan, Ann Arbor, Michigan 48109 ; Teratology Unit, Pediatric Genetics, TC 1924, Box 0318, University Hospitals, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Teratology Unit, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 12210009 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34558/1/10064_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/tera.10064 | en_US |
dc.identifier.source | Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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