R726L androgen receptor mutation is uncommon in prostate cancer families in the united states
dc.contributor.author | Gruber, Stephen B. | en_US |
dc.contributor.author | Chen, Hong | en_US |
dc.contributor.author | Tomsho, Lynn P. | en_US |
dc.contributor.author | Lee, Nana | en_US |
dc.contributor.author | Perrone, Erin E. | en_US |
dc.contributor.author | Cooney, Kathleen A. | en_US |
dc.date.accessioned | 2006-04-19T13:49:19Z | |
dc.date.available | 2006-04-19T13:49:19Z | |
dc.date.issued | 2003-03-01 | en_US |
dc.identifier.citation | Gruber, Stephen B.; Chen, Hong; Tomsho, Lynn P.; Lee, Nana; Perrone, Erin E.; Cooney, Kathleen A. (2003)."R726L androgen receptor mutation is uncommon in prostate cancer families in the united states." The Prostate 54(4): 306-309. <http://hdl.handle.net/2027.42/34764> | en_US |
dc.identifier.issn | 0270-4137 | en_US |
dc.identifier.issn | 1097-0045 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34764 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12539229&dopt=citation | en_US |
dc.description.abstract | Background A mutation in the androgen receptor ( AR ) gene, namely AR R726L, was described in 2% of Finnish men with sporadic or familial prostate cancer and was associated with an approximately sixfold increased risk of prostate cancer. We set out to determine the incidence of this mutation in a sample of men with either early-onset and/or familial prostate cancer in the United States. Methods Five hundred forty-eight men with prostate cancer from 411 unrelated families participating in the University of Michigan Prostate Cancer Genetics Project (PCGP) were studied. Allele-specific oligonucleotide hybridization was used to detect the presence of the AR R726L mutation in germline DNA. Results None of the 548 prostate cancer patients studied, including 513 White, 29 African American, 3 Asian, and 3 Hispanic men, were found to carry the AR R726L allele. Therefore, the prevalence of this allele is significantly less than that observed among Finnish men with prostate cancer (Fisher's exact test, P = 0.002). Conclusions The AR R726L allele does not account for a significant proportion of early-onset and/or familial prostate cancer in the United States. Prostate 54: 306–309, 2003. © 2003 Wiley-Liss, Inc. | en_US |
dc.format.extent | 120825 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | R726L androgen receptor mutation is uncommon in prostate cancer families in the united states | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Veterans Affairs Medical Center, Ann Arbor, Michigan ; 7310 CCGC, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0946. | en_US |
dc.identifier.pmid | 12539229 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34764/1/10195_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/pros.10195 | en_US |
dc.identifier.source | The Prostate | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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