Age, gender, and bone lamellae elastic moduli
dc.contributor.author | Hoffler, C. Edward | en_US |
dc.contributor.author | Moore, K. E. | en_US |
dc.contributor.author | Kozloff, K. | en_US |
dc.contributor.author | Zysset, P. K. | en_US |
dc.contributor.author | Goldstein, Steven A. | en_US |
dc.date.accessioned | 2006-04-19T13:58:42Z | |
dc.date.available | 2006-04-19T13:58:42Z | |
dc.date.issued | 2000-05 | en_US |
dc.identifier.citation | Hoffler, C. E.; Moore, K. E.; Kozloff, K.; Zysset, P. K.; Goldstein, S. A. (2000)."Age, gender, and bone lamellae elastic moduli." Journal of Orthopaedic Research 18(3): 432-437. <http://hdl.handle.net/2027.42/34918> | en_US |
dc.identifier.issn | 0736-0266 | en_US |
dc.identifier.issn | 1554-527X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34918 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10937630&dopt=citation | en_US |
dc.description.abstract | To enhance preventative and therapeutic strategies for metabolic bone diseases and bone fragility disorders, we began to explore the physical properties of bone tissue at the cellular level. Proximal femurs were harvested from 27 cadavera (16 male and 11 female) for in vitro measurement of the mechanical properties. We measured the variations in lamellar-level elastic modulus and hardness in human bone as a function of age and gender to identify microstructural properties responsible for age and gender-related reductions in the mechanical integrity. The lateral femoral necks were examined, and age, gender, height, body mass, and body mass index were not found to correlate with lamellar-level elastic modulus or hardness. This result was consistent for osteonal, interstitial, and trabecular tissue. These data suggest that increased bone mass maintenance, known to occur in heavier individuals, is not accompanied by increases in the lamellar-level elastic modulus or hardness. The independence of elastic modulus and hardness from age and gender suggests that age and gender-related decreases in mechanical integrity do not involve alterations in elastic modulus or hard ness of the extracellular matrix. Lamellar-level ultimate, fatigue, and fracture toughness properties should also be investigated. Other factors, such as tissue mass and organization, may also contribute to age and gender-related decreases in the mechanical integrity. | en_US |
dc.format.extent | 646680 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.title | Age, gender, and bone lamellae elastic moduli | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A. ; Orthopaedic Research Laboratories, Department of Surgery, University of Michigan, G-0161 400 North Ingalls Street, Ann Arbor, MI 48109-0486, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Applied Mechanics and Reliability Analysis, Department of Mechanical Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland | en_US |
dc.identifier.pmid | 10937630 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34918/1/1100180315_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jor.1100180315 | en_US |
dc.identifier.source | Journal of Orthopaedic Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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