Lod scores for gene mapping in the presence of marker map uncertainty
dc.contributor.author | Stringham, Heather M. | en_US |
dc.contributor.author | Boehnke, Michael | en_US |
dc.date.accessioned | 2006-04-19T13:59:29Z | |
dc.date.available | 2006-04-19T13:59:29Z | |
dc.date.issued | 2001-07 | en_US |
dc.identifier.citation | Stringham, Heather M.; Boehnke, Michael (2001)."Lod scores for gene mapping in the presence of marker map uncertainty." Genetic Epidemiology 21(1): 31-39. <http://hdl.handle.net/2027.42/34934> | en_US |
dc.identifier.issn | 0741-0395 | en_US |
dc.identifier.issn | 1098-2272 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34934 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11443732&dopt=citation | en_US |
dc.description.abstract | Multipoint lod scores are typically calculated for a grid of locus positions, moving the putative disease locus across a fixed map of genetic markers. Changing the order of a set of markers and/or the distances between the markers can make a substantial difference in the resulting lod score curve and the location and height of its maximum. The typical approach of using the best maximum likelihood marker map is not easily justified if other marker orders are nearly as likely and give substantially different lod score curves. To deal with this problem, we propose three weighted multipoint lod score statistics that make use of information from all plausible marker orders. In each of these statistics, the information conditional on a particular marker order is included in a weighted sum, with weight equal to the posterior probability of that order. We evaluate the type 1 error rate and power of these three statistics on the basis of results from simulated data, and compare these results to those obtained using the best maximum likelihood map and the map with the true marker order. We find that the lod score based on a weighted sum of maximum likelihoods improves on using only the best maximum likelihood map, having a type 1 error rate and power closest to that of using the true marker order in the simulation scenarios we considered. Genet. Epidemiol. 21:31–39, 2001. © 2001 Wiley-Liss, Inc. | en_US |
dc.format.extent | 51109 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Lod scores for gene mapping in the presence of marker map uncertainty | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor ; Department of Biostatistics, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109-2029 | en_US |
dc.identifier.pmid | 11443732 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34934/1/1016_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/gepi.1016 | en_US |
dc.identifier.source | Genetic Epidemiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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