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Analysis of a zebrafish semaphorin reveals potential functions in vivo

dc.contributor.authorHalloran, Mary C.en_US
dc.contributor.authorSeverance, Shawn M.en_US
dc.contributor.authorYee, Charles S.en_US
dc.contributor.authorGemza, Debra L.en_US
dc.contributor.authorRaper, Jonathan A.en_US
dc.contributor.authorKuwada, John Y.en_US
dc.date.accessioned2006-04-19T14:13:46Z
dc.date.available2006-04-19T14:13:46Z
dc.date.issued1999-01en_US
dc.identifier.citationHalloran, Mary C.; Severance, Shawn M.; Yee, Charles S.; Gemza, Debra L.; Raper, Jonathan A.; Kuwada, John Y. (1999)."Analysis of a zebrafish semaphorin reveals potential functions in vivo." Developmental Dynamics 214(1): 13-25. <http://hdl.handle.net/2027.42/35164>en_US
dc.identifier.issn1058-8388en_US
dc.identifier.issn1097-0177en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/35164
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9915572&dopt=citationen_US
dc.description.abstractThe semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. Dev Dyn 1999;214:13–25. © 1999 Wiley-Liss, Inc.en_US
dc.format.extent1231418 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleAnalysis of a zebrafish semaphorin reveals potential functions in vivoen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michigan ; Department of Biology, University of Michigan, Ann Arbor, MI 48109–1048.en_US
dc.contributor.affiliationotherDepartment of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvaniaen_US
dc.identifier.pmid9915572en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/35164/1/2_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/(SICI)1097-0177(199901)214:1<13::AID-DVDY2>3.0.CO;2-3en_US
dc.identifier.sourceDevelopmental Dynamicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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