Serotonin in autism and pediatric epilepsies
dc.contributor.author | Chugani, Diane C. | en_US |
dc.date.accessioned | 2006-04-19T14:16:16Z | |
dc.date.available | 2006-04-19T14:16:16Z | |
dc.date.issued | 2004-05 | en_US |
dc.identifier.citation | Chugani, Diane C. (2004)."Serotonin in autism and pediatric epilepsies." Mental Retardation and Developmental Disabilities Research Reviews 10(2): 112-116. <http://hdl.handle.net/2027.42/35205> | en_US |
dc.identifier.issn | 1080-4013 | en_US |
dc.identifier.issn | 1098-2779 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35205 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15362166&dopt=citation | en_US |
dc.description.abstract | Serotonergic abnormalities have been reported in both autism and epilepsy. This association may provide insights into underlying mechanisms of these disorders because serotonin plays an important neurotrophic role during brain development—and there is evidence for abnormal cortical development in both autism and some forms of epilepsy. This review explores the hypothesis that an early disturbance in the serotonin system affects cortical development and the development of thalamocortical innervation, and is a potential mechanism, common to autism and pediatric epilepsies associated with cortical dysplasia. An argument is made that cortical malformation leads to abnormalities of thalamocortical connectivity, and that serotonin plays a critical role in this process. Finally, a role for altered metabolism of the serotonin precursur, tryptophan, in both epilepsy and autism is discussed. MRDD Research Reviews 2004;10:112–116. © 2004 Wiley-Liss, Inc. | en_US |
dc.format.extent | 95819 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Serotonin in autism and pediatric epilepsies | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Social Work | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Departments of Pediatrics and Radiology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan ; Children's Hospital of Michigan, PET Center, 3901 Beaubien Blvd., Detroit, MI 48201 | en_US |
dc.identifier.pmid | 15362166 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35205/1/20021_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mrdd.20021 | en_US |
dc.identifier.source | Mental Retardation and Developmental Disabilities Research Reviews | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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