Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass
dc.contributor.author | Marrero, Jorge A. | en_US |
dc.contributor.author | Hussain, Hero K. | en_US |
dc.contributor.author | Nghiem, Hahn V. | en_US |
dc.contributor.author | Umar, Ramsey | en_US |
dc.contributor.author | Fontana, Robert John | en_US |
dc.contributor.author | Lok, Anna Suk-Fong | en_US |
dc.date.accessioned | 2006-04-19T14:21:33Z | |
dc.date.available | 2006-04-19T14:21:33Z | |
dc.date.issued | 2005-03 | en_US |
dc.identifier.citation | Marrero, Jorge A.; Hussain, Hero K.; Nghiem, Hahn V.; Umar, Ramsey; Fontana, Robert J.; Lok, Anna S. (2005)."Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass." Liver Transplantation 11(3): 281-289. <http://hdl.handle.net/2027.42/35287> | en_US |
dc.identifier.issn | 1527-6465 | en_US |
dc.identifier.issn | 1527-6473 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35287 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15719410&dopt=citation | en_US |
dc.description.abstract | In the United States, cirrhotic patients with known or suspected hepatocellular carcinoma (HCC) are prioritized for liver transplantation. Noninvasive criteria for the diagnosis of HCC rely on arterial enhancement of a mass. The aim of this study was to determine whether clinical, laboratory, and / or radiologic data can improve the prediction of HCC in cirrhotic patients with an arterially-enhancing mass. Between May 2002 and June 2003, dynamic gadolinium-enhanced magnetic resonance imaging (MRI) of consecutive patients with liver cirrhosis and a solid mass were reviewed by 2 radiologists blinded to the clinical diagnosis. Clinical, laboratory, and radiologic data were recorded for all patients. A total of 94 patients with cirrhosis and an arterially-enhancing liver mass were studied, 66 (70%) of whom had HCC. Alpha-fetoprotein (AFP) >20 ng/mL ( P = .029), tumor size >2 cm ( P = .0018), and delayed hypointensity ( P = .0001) were independent predictors of HCC. Delayed hypointensity of an arterially-enhancing mass had a sensitivity of 89% and a specificity of 96% for HCC. The presence of delayed hypointensity was the only independent predictor of HCC among patients with arterially-enhancing lesions <2 cm (odds ratio, 6.3; 95% confidence interval [CI], 1.8-13), with a sensitivity of 80% and a specificity of 95%. In conclusion, delayed hypointensity of an arterially-enhancing mass was the strongest independent predictor of HCC, regardless of the size of the lesion. If additional studies confirm our results, the noninvasive criteria utilized to make a diagnosis of HCC should be revised. (Liver Transpl 2005;11:281–289.) | en_US |
dc.format.extent | 209233 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Surgery | en_US |
dc.title | Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI ; Telephone: 734-615-4628; FAX: 734-936-7392 ; J.A.M. and H.K.H. contributed equally to this manuscript. ; Division of Gastroenterology, University of Michigan, 3912 Taubman Center, Ann Arbor, MI 48109-0362 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 15719410 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35287/1/20357_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/lt.20357 | en_US |
dc.identifier.source | Liver Transplantation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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