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Methylenetetrahydrofolate reductase: A common human polymorphism and its biochemical implications

dc.contributor.authorMatthews, Rowena Greenen_US
dc.date.accessioned2006-04-19T14:21:36Z
dc.date.available2006-04-19T14:21:36Z
dc.date.issued2002en_US
dc.identifier.citationMatthews, Rowena G. (2002)."Methylenetetrahydrofolate reductase: A common human polymorphism and its biochemical implications." The Chemical Record 2(1): 4-12. <http://hdl.handle.net/2027.42/35288>en_US
dc.identifier.issn1527-8999en_US
dc.identifier.issn1528-0691en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/35288
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11933257&dopt=citationen_US
dc.description.abstractMethlenetetrahydrofolate (CH 2 -H 4 folate) is required for the conversion of homocysteine to methionine and of dUMP to dTMP in support of DNA synthesis, and also serves as a major source of one carbon unit for purine biosynthesis. This review presents biochemical studies of a human polymorphism in methylenetetrahydrofolate reductase, which catalyzes the reaction shown below. The mutation decreases the flux of CH 2 -H 4 folate into CH 3 -H 4 folate, and is associated with both beneficial and deleterious effects that can be traced to the molecular effect of the substitution of alanine 222 by valine. © 2002 The Japan Chemical Journal Forum and John Wiley & Sons, Inc. Chem Rec 2: 4–12, 2002en_US
dc.format.extent380196 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subject.otherChemistryen_US
dc.titleMethylenetetrahydrofolate reductase: A common human polymorphism and its biochemical implicationsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumBiophysics Research Division, The University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109-1055 ; Department of Biological Chemistry, The University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109-1055 ; Biophysics Research Division and Department of Biological Chemistry, The University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109-1055en_US
dc.identifier.pmid11933257en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/35288/1/10006_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/tcr.10006en_US
dc.identifier.sourceThe Chemical Recorden_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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