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Cytologic features of small-cell carcinoma on ThinPrep®

dc.contributor.authorBavikatty, Neil R.en_US
dc.contributor.authorMichael, Claire W.en_US
dc.date.accessioned2006-04-19T14:23:03Z
dc.date.available2006-04-19T14:23:03Z
dc.date.issued2003-07en_US
dc.identifier.citationBavikatty, Neil R.; Michael, Claire W. (2003)."Cytologic features of small-cell carcinoma on ThinPrep®." Diagnostic Cytopathology 29(1): 8-12. <http://hdl.handle.net/2027.42/35311>en_US
dc.identifier.issn8755-1039en_US
dc.identifier.issn1097-0339en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/35311
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12827707&dopt=citationen_US
dc.description.abstractThe use of ThinPrep® (TP) technology for fine-needle aspiration (FNA) cytology has become widely accepted. However, some literature suggests that small-cell carcinoma may present a diagnostic pitfall due to morphologic alterations. In this study, we retrospectively compared 14 FNA of small-cell carcinoma prepared using TP with corresponding conventional smears (CS). We also examined the TP appearance of 23 other small round-cell lesions in order to determine if differential diagnostic features were preserved. TP and CS were evaluated semiquantitatively for background, architecture, chromatin quality, nuclear molding, nuclear smearing, nucleolar prominence, amount of cytoplasm, nuclear size, and single-cell necrosis. The data were analyzed using the McNemar Χ 2 test. TP slides of small-cell carcinoma showed a cleaner background than CS ( P < 0.005). Although some degree of nuclear molding was preserved, it was decreased in amount ( P < 0.025) and subtler in quality. Similarly, nuclear smearing was present but decreased in amount ( P < 0.05), and less prominent qualitatively. The amount of discernible cytoplasm was greater on TP ( P < 0.005). No significant differences were found for any of the other parameters studied. The presence of nuclear molding was the single most useful feature in differentiating small-cell carcinoma from other small round-cell tumors on TP. Small-cell carcinoma may be diagnosed with confidence by FNA using TP. However, pathologists should be aware of certain morphologic alterations in order to avoid diagnostic pitfalls. Diagn. Cytopathol. 2003;29:8–12. © 2003 Wiley-Liss, Inc.en_US
dc.format.extent631591 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleCytologic features of small-cell carcinoma on ThinPrep®en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michigan ; Department of Pathology, University of Michigan Hospitals, 1500 E. Medical Center Drive, Room 2G332, Box 0054, Ann Arbor, MI 48109-0054en_US
dc.identifier.pmid12827707en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/35311/1/10297_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/dc.10297en_US
dc.identifier.sourceDiagnostic Cytopathologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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