Connective tissue activation
dc.contributor.author | Cabral, Antonio R. | en_US |
dc.contributor.author | Castor, C. William | en_US |
dc.date.accessioned | 2006-04-28T16:23:14Z | |
dc.date.available | 2006-04-28T16:23:14Z | |
dc.date.issued | 1983-11 | en_US |
dc.identifier.citation | Cabral, A.; Castor, C. W. (1983)."Connective tissue activation." Arthritis & Rheumatism 26(11): 1362-1369. <http://hdl.handle.net/2027.42/37761> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37761 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6639695&dopt=citation | en_US |
dc.description.abstract | Four normal (NF) and 4 scleroderma skin fibro-blast (SF) strains were compared with respect to 1) basal 14 C-glucosamine and 35 SO 4 -labeled glycosaminoglycan (GAG) synthesis, 2) responsiveness to autacoid mediators, and 3) performance following maximal stimulation. Under basal conditions, SF synthesized and secreted 2–3 times more radioactive hyaluronic acid than the NF ( P < 0.001); molecular volume by gel chromatography was similar and suggested a high molecular weight product. SF were essentially as responsive to normal lymphoid and platelet factors as were NF. No consistent qualitative or quantitative differences in sulfated GAG synthesis were noted between the 2 groups of cells. Incubation of NF and SF with a false “core protein” such as p-nitrophenyl-Β-D-xyloside suggested that synthesis of the core protein was rate limiting; SF and NF were equally facile in SO 4 -GAG chain synthesis in the presence of a Β-xyloside. SF appear to retain in vitro a partially activated state for many generations, at least with respect to hyaluronic acid synthesis. | en_US |
dc.format.extent | 709605 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Connective tissue activation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor. | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor. ; Rackham Arthritis Research Unit, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 6639695 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37761/1/1780261109_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.1780261109 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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