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| Title: | Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis |
| Authors: | Richardson, Bruce C.
Scheinbart, Lee
Strahler, John R.
Gross, Laura
Hanash, Samir
Johnson, Marcia A. |
| Issue Date: | Nov-1990 |
| Publisher: | John Wiley & Sons, Inc. |
| Citation: | Richardson, Bruce; Scheinbart, Lee; Strahler, John; Gross, Laura; Hanash, Samir; Johnson, Marcia (1990)."Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis." Arthritis & Rheumatism 33(11): 1665-1673. <http://hdl.handle.net/2027.42/37783> |
| Abstract: | Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease. |
| URI: | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db
=pubmed&list_uids=2242063&dopt=citation |
| ISSN: | 0004-3591
1529-0131 |
| DOI: | 10.1002/art.1780331109 |
| PMID: | 2242063 |
| Appears in Collections: | Interdisciplinary and Peer-Reviewed
Rheumatology, Division of
Internal Medicine, Department of
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Files in This Item:
| File |
Description |
Size | Format | |
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| 1780331109_ftp.pdf | | 900Kb | Adobe PDF | View/Open |
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