View Item 

Show simple item record

Lymphocyte function—associated antigen 1 overexpression and t cell autoreactivity

dc.contributor.authorRichardson, Bruce C.en_US
dc.contributor.authorO'Rourke, Kenneth S.en_US
dc.date.accessioned2006-04-28T16:25:18Z
dc.date.available2006-04-28T16:25:18Z
dc.date.issued1994-08en_US
dc.identifier.citationRichardson, Bruce; O'Rourke, Kenneth (1994)."Lymphocyte function—associated antigen 1 overexpression and t cell autoreactivity." Arthritis & Rheumatism 37(9): 1363-1372. <http://hdl.handle.net/2027.42/37802>en_US
dc.identifier.issn0004-3591en_US
dc.identifier.issn1529-0131en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/37802
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7524510&dopt=citationen_US
dc.description.abstractObjective . To determine if DNA methylation inhibitors make T cells autoreactive by inducing lymphocyte function—associated antigen type 1 (LFA–1) (CD11a/CD18) overexpression. Methods . T cell clones were treated with 3 distinct DNA methylation inhibitors or were stably transfected with a CD18 cDNA in a mammalian expression vector, and the effects on LFA–1 expression and activation requirements were examined. Results . LFA–1 overexpression, caused by DNA methylation inhibitors or by transfection, correlates with the development of autoreactivity. Conclusion . LFA–1 overexpression may contribute to T cell autoreactivity.en_US
dc.format.extent989386 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherRheumatologyen_US
dc.titleLymphocyte function—associated antigen 1 overexpression and t cell autoreactivityen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, and the Ann Arbor Veterans Administration Hospital ; R4540 Kresge 1, Ann Arbor, MI 48109–0531en_US
dc.contributor.affiliationotherBowman Gray School of Medicine, Winston–Salem, North Carolinaen_US
dc.identifier.pmid7524510en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/37802/1/1780370915_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/art.1780370915en_US
dc.identifier.sourceArthritis & Rheumatismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
1780370915_ftp.pdf
Size:
966.1KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.