Fas ligation triggers apoptosis in macrophages but not endothelial cells
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.contributor.author | Lalwani, Narendra D. | en_US |
dc.contributor.author | Johnson, Kent J. | en_US |
dc.contributor.author | Marks, Rory M. | en_US |
dc.date.accessioned | 2006-04-28T16:33:21Z | |
dc.date.available | 2006-04-28T16:33:21Z | |
dc.date.issued | 1994-11 | en_US |
dc.identifier.citation | Richardson, Bruce C.; Lalwani, Narendra D.; Johnson, Kent J.; Marks, Rory M. (1994)."Fas ligation triggers apoptosis in macrophages but not endothelial cells." European Journal of Immunology 24(11): 2640-2645. <http://hdl.handle.net/2027.42/37964> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/37964 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7525299&dopt=citation | en_US |
dc.description.abstract | The reticuloendothelial system includes macrophages and endothelial cells. These cells are produced and destroyed in vivo with a precision that implies the existence of homeostatic mechanisms. The stimuli for endothelial cell proliferation and monocyte production are becoming well characterized. However, the mechanisms involved in eliminating these cells are poorly understood. One mechanism involved in cellular elimination is apoptosis, which can be triggered in some cells by ligation of the Fas molecule. In this report we have investigated whether macrophages and endothelial cells express the Fas molecule, and whether Fas transmits an apoptosis-inducing signal in these cells. We demonstrate that macrophages express Fas and readily undergo apoptosis when cultured with anti-Fas. In contrast, while endothelial cells can express the Fas molecule, Fas ligation is insufficient to induce apoptosis. These results suggest differential regulation of Fas function among cells of the reticuloendothelial system, and imply different mechanisms of homeostasis. | en_US |
dc.format.extent | 695547 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | WILEY-VCH Verlag GmbH | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | Fas ligation triggers apoptosis in macrophages but not endothelial cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor ; Ann Arbor Veterans Administration Hospital, Ann Arbor ; R4540 Kresge 1, Ann Arbor MI 48109-0531, USA (Fax: 3 13-7 63-20 25) | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationother | Department of Pathology & Experimental Toxicology Parke-Davis Pharmaceutical Research, Warner-Lambert Co., Ann Arbor | en_US |
dc.identifier.pmid | 7525299 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/37964/1/1830241111_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(ISSN)1521-4141 | en_US |
dc.identifier.source | European Journal of Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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