At-risk Persons' attitudes toward presymptomatic and prenatal testing of Huntington disease in Michigan
dc.contributor.author | Markel, Dorene S. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.contributor.author | Penney, John B. | en_US |
dc.date.accessioned | 2006-04-28T16:47:49Z | |
dc.date.available | 2006-04-28T16:47:49Z | |
dc.date.issued | 1987-02 | en_US |
dc.identifier.citation | Markel, Dorene S.; Young, Anne B.; Penney, John B. (1987)."At-risk Persons' attitudes toward presymptomatic and prenatal testing of Huntington disease in Michigan." American Journal of Medical Genetics 26(2): 295-305. <http://hdl.handle.net/2027.42/38242> | en_US |
dc.identifier.issn | 0148-7299 | en_US |
dc.identifier.issn | 1096-8628 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38242 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2949613&dopt=citation | en_US |
dc.description.abstract | One hundred fifty-five individuals at 50% risk of inheriting Huntington disease (HD) were given a questionnaire surveying their sociodemographic characteris-tics, experience with HD, and attitudes toward presymptomatic and prenatal testing in HD. About two-thirds (63.2%) of the persons indicated they would take a presymptomatic test even if no specific treatment was available. Although one-half (49%) of the respondents stated they would make use of a prenatal test, only 43% of these individuals would decide to terminate a heterozygous fetus. Presym-patomatic test results indicating carrier status would influence some of the respondents' decisions about marriage and childbearing. This strong interest of at-risk persons to make use of both presymptomatic and prenatal diagnosis in HD indicates the need for well-organized testing programs. These programs must be designed to address the genetic, psychosocial, and ethical issues that may arise in the use of this type of genetic test. | en_US |
dc.format.extent | 632868 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | At-risk Persons' attitudes toward presymptomatic and prenatal testing of Huntington disease in Michigan | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Neurology, Ann Arbor, Michigan ; Department of Neurology, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron Street, Ann Arbor, MI 48104-1687 | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Neurology, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Neurology, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 2949613 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38242/1/1320260207_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ajmg.1320260207 | en_US |
dc.identifier.source | American Journal of Medical Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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