The effects of galactosamine-induced hepatic failure upon blood-brain barrier permeability
dc.contributor.author | Lo, Warren D. | en_US |
dc.contributor.author | Ennis, Steven R. | en_US |
dc.contributor.author | Goldstein, Gary W. | en_US |
dc.contributor.author | McNeely, David L. | en_US |
dc.contributor.author | Betz, A. Lorris | en_US |
dc.date.accessioned | 2006-04-28T16:52:54Z | |
dc.date.available | 2006-04-28T16:52:54Z | |
dc.date.issued | 1987-05 | en_US |
dc.identifier.citation | Lo, Warren D.; Ennis, Steven R.; Goldstein, Gary W.; McNeely, David L.; Betz, A. Lorris (1987)."The effects of galactosamine-induced hepatic failure upon blood-brain barrier permeability." Hepatology 7(3): 452-456. <http://hdl.handle.net/2027.42/38333> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38333 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3570156&dopt=citation | en_US |
dc.description.abstract | The role of changes in blood-brain barrier permeability in the pathogenesis of hepatic encephalopathy remains uncertain. To test the hypothesis that brain microvessel permeability is nonselectively increased in hepatic encephalopathy we measured the blood-brain barrier permeability-surface area product in rats with acute liver failure induced by intraperitoneal injection of galactosamine. The permeability-surface area products to the diffusion-limited tracers, sucrose and methylaminoisobutyric acid, were determined as a measure of blood-brain barrier permeability. Animals were examined 24, 36 and 42 hr after injection, at times when they were stuporous, but not comatose. No significant elevations of the permeability-surface area products for either compound were detected in clinically affected experimental animals when compared to controls. Our results indicate there is no generalized increase in brain vascular permeability during hepatic insufficiency in precomatose animals. | en_US |
dc.format.extent | 510667 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | W.B. Saunders | en_US |
dc.publisher | Wiley Periodiocals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | The effects of galactosamine-induced hepatic failure upon blood-brain barrier permeability | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan, Ann Arbor, Michigan 48109 and Columbus Children's Hospital, Columbus, Ohio 43205 | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan, Ann Arbor, Michigan 48109 and Columbus Children's Hospital, Columbus, Ohio 43205 | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan, Ann Arbor, Michigan 48109 and Columbus Children's Hospital, Columbus, Ohio 43205 | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan, Ann Arbor, Michigan 48109 and Columbus Children's Hospital, Columbus, Ohio 43205 | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan, Ann Arbor, Michigan 48109 and Columbus Children's Hospital, Columbus, Ohio 43205 ; University of Michigan Medical Center, Pediatric Neurology Research, R6060 Kresge Research II, Box 0570, Ann Arbor, Michigan 48109–0570 | en_US |
dc.identifier.pmid | 3570156 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38333/1/1840070307_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.1840070307 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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