Biochemical and histopathological correlation in liver transplant: The first 180 days
dc.contributor.author | Henley, Keith S. | en_US |
dc.contributor.author | Lucey, Michael R. | en_US |
dc.contributor.author | Appelman, Henry D. | en_US |
dc.contributor.author | Baliga, Prabhakar | en_US |
dc.contributor.author | Brown, Kimberly A. | en_US |
dc.contributor.author | Burtch, Gordon D. | en_US |
dc.contributor.author | Campbell, Darrell A. | en_US |
dc.contributor.author | Ham, John M. | en_US |
dc.contributor.author | Merion, Robert M. | en_US |
dc.contributor.author | Turcotte, Jeremiah G. | en_US |
dc.date.accessioned | 2006-04-28T16:55:24Z | |
dc.date.available | 2006-04-28T16:55:24Z | |
dc.date.issued | 1992-09 | en_US |
dc.identifier.citation | Henley, Keith S.; Lucey, Michael R.; Appelman, Henry D.; Baliga, Prabhakar; Brown, Kimberly A.; Burtch, Gordon D.; Campbell, Darrell A.; Ham, John M.; Merion, Robert M.; Turcotte, Jeremiah G. (1992)."Biochemical and histopathological correlation in liver transplant: The first 180 days." Hepatology 16(3): 688-693. <http://hdl.handle.net/2027.42/38382> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38382 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1505912&dopt=citation | en_US |
dc.description.abstract | It is not known whether the histopathology of the liver allograft can be predicted from biochemical measurements in serum with the same confidence as in the native liver. To answer this question we compared the histopathological diagnoses in 170 biopsy specimens from 70 adult transplant recipients obtained during the first 180 days, with the concentrations of the serum bilirubin and the activities of AST, ALT and alkaline phosphatase measured at the same time. The most frequent diagnosis was cholestasis (n = 45), which was mild, moderate or severe and which may have been complicated by rejection (n = 28) or ischemia (n = 14). Hepatitis (n = 14), ischemia with rejection (n = 6) and spotty focal necrosis (n = 6) were diagnosed less frequently. Fifteen biopsy specimens were reported as histopathologically normal. In general, biochemical measurements discriminated poorly between different histopathological diagnoses. The histopathologically normal liver often showed an abnormal pattern of enzymes and an increase in the serum bilirubin level. As a result histopathologically normal biopsy specimens were indistinguishable biochemically from those with hepatitis. When two pathological conditions were found to coexist (e.g., cholestasis with either rejection or ischemic necrosis, or ischemic necrosis with rejection), the effect on the serum biochemistry was usually not additive and in some instances returned the biochemical abnormalities toward normal. With the exception of the serum bilirubin level, which increased with the severity of uncomplicated cholestasis, we could not identify a specific pattern of biochemical changes corresponding to a given histopathological diagnosis. We suggest that until more specific noninvasive methods of monitoring the transplanted liver are developed protocol liver biopsies offer the best means of identifying significant pathological conditions in liver allografts. (H EPATOLOGY 1992;16:688–693.) | en_US |
dc.format.extent | 724370 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | W.B. Saunders | en_US |
dc.publisher | Wiley Periodiocals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Biochemical and histopathological correlation in liver transplant: The first 180 days | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Departments of Internal Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109 ; 3912 Taubman Center, The University of Michigan Medical Center, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Internal Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Internal Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | The Departments of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 1505912 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38382/1/1840160312_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.1840160312 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.