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Is the multidrug resistance an ATP channel?

dc.contributor.authorGumucio, Jorge J.en_US
dc.contributor.authorArias, Irwin M.en_US
dc.date.accessioned2006-04-28T16:56:06Z
dc.date.available2006-04-28T16:56:06Z
dc.date.issued1993-07en_US
dc.identifier.citationGumucio, Jorge J.; Arias, Irwin M. (1993)."Is the multidrug resistance an ATP channel?." Hepatology 18(1): 216-217. <http://hdl.handle.net/2027.42/38396>en_US
dc.identifier.issn0270-9139en_US
dc.identifier.issn1527-3350en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/38396
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7686878&dopt=citationen_US
dc.description.abstractThe multidrug resistance ( mdr1 ) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increaed levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.en_US
dc.format.extent280946 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherW.B. Saundersen_US
dc.publisherWiley Periodiocals, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherHepatologyen_US
dc.titleIs the multidrug resistance an ATP channel?en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine Division of Gastroenterology (111D) VA Medical Center/University of Michigan Ann Arbor, Michigan 48105en_US
dc.contributor.affiliationotherDepartment of Physiology Tufts University School of Medicine Boston, Massachusetts 02111en_US
dc.identifier.pmid7686878en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/38396/1/1840180131_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/hep.1840180131en_US
dc.identifier.sourceHepatologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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