Gene transefer as a new mode of vaccination: Implications for HCV
dc.contributor.author | Gumucio, Jorge J. | en_US |
dc.contributor.author | McDonnell, W. Michael | en_US |
dc.date.accessioned | 2006-04-28T16:56:18Z | |
dc.date.available | 2006-04-28T16:56:18Z | |
dc.date.issued | 1993-09 | en_US |
dc.identifier.citation | Gumucio, Jorge J.; McDonnell, W. Michael (1993)."Gene transefer as a new mode of vaccination: Implications for HCV." Hepatology 18(3): 696-698. <http://hdl.handle.net/2027.42/38400> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38400 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8395461&dopt=citation | en_US |
dc.description.abstract | Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different strains of virus, in contrast to antibodies, which are generally strain-specific. The generation of such CTLs in vivo usually requires endogenous expression of the antigen, as occurs in the case of virus infection. To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleoprotein was injected into the quadriceps of BALB/c mice. This resulted in the generation of nucleoproteinspecific CTLs and protection from a subsequent challenge with a heterologous strain of influenza A virus, as measured by decreased viral lung titers, inhibition of mass loss, and increased survival. | en_US |
dc.format.extent | 422580 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | W.B. Saunders | en_US |
dc.publisher | Wiley Periodiocals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Gene transefer as a new mode of vaccination: Implications for HCV | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine Division of Gastroenterology (111D) VA Medical Center/University of Michigan Ann Arbor, Michigan 48105 | en_US |
dc.contributor.affiliationum | Department of Internal Medicine University of Michigan Medical School Ann Arbor, Michigan 48109–0362 | en_US |
dc.identifier.pmid | 8395461 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38400/1/1840180330_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.1840180330 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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