Circulating 5-hydroxytryptamine concentrations in preterm newborns
dc.contributor.author | Schumacher, Robert E. | en_US |
dc.contributor.author | Farrell, P. M. | en_US |
dc.contributor.author | Olson, E. B. | en_US |
dc.date.accessioned | 2006-04-28T17:06:01Z | |
dc.date.available | 2006-04-28T17:06:01Z | |
dc.date.issued | 1987-03 | en_US |
dc.identifier.citation | Schumacher, R. E.; Farrell, P. M.; Olson, E. B. (1987)."Circulating 5-hydroxytryptamine concentrations in preterm newborns." Pediatric Pulmonology 3(2): 117-122. <http://hdl.handle.net/2027.42/38593> | en_US |
dc.identifier.issn | 8755-6863 | en_US |
dc.identifier.issn | 1099-0496 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38593 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3588055&dopt=citation | en_US |
dc.description.abstract | Alterations in circulating 5-hydroxytryptamine (5-HT) concentrations play a role in the pathophysiology of respiratory failure in adults. We undertook a study to develop a micromethod and measure circulating free 5-HT concentrations in preterm newborns with and without respiratory distress. Forty-six samples of platelet-poor plasma were obtained from 29 preterm newborns with varying degrees of respiratory distress. Samples were taken on days 2–3 and 6–7 of life. For measuring 5-HT concentrations we used a precolumn sample enhancement technique followed by ion exchange HPLC with electrochemical detection. The assay allowed detection of extremely small (50 pg) amounts of 5-HT from small (0.2 ml) amounts of blood. The mean 5-HT concentration on days 2–3 was 1.77 ± 0.74 ng/ml (mean ± 95% confidence limits) and on days 6–7 was 0.69 ± 0 23 ng/ml. This represented a significant fall in 5-HT concentrations (P = 0.01). All of 16 paired serial samples fell with time (P = 0.006). We conclude that platelet-poor plasma 5-HT concentrations in premature newborns are low, that there is a significant decline in these values over the first week of life, and that, in contrast with adults, the presence of respiratory failure is not associated with increased free 5-HT concentrations. The low 5-HT concentrations seen in newborns may reflect the ability to increase pulmonary uptake. Pediatr Pulmonol 1987; 3:117–122 . | en_US |
dc.format.extent | 506233 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Miscellaneous Medical | en_US |
dc.title | Circulating 5-hydroxytryptamine concentrations in preterm newborns | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Preventative Medicine, University of Michigan Medical Center, Ann Arbor, Michigan ; University of Wisconsin and Madison General Hospital, Madison, Wisconsin ; Department of Pediatrics, Section of Newborn Services, University of Michigan Medical Center, Box 0254, L3023 Women's Hospital, Ann Arbor, MI 48109-0254 | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Preventative Medicine, University of Michigan Medical Center, Ann Arbor, Michigan ; University of Wisconsin and Madison General Hospital, Madison, Wisconsin | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Preventative Medicine, University of Michigan Medical Center, Ann Arbor, Michigan ; University of Wisconsin and Madison General Hospital, Madison, Wisconsin | en_US |
dc.identifier.pmid | 3588055 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38593/1/1950030214_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ppul.1950030214 | en_US |
dc.identifier.source | Pediatric Pulmonology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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